Trim27 MGI Mouse Gene Detail - MGI:97904 - tripartite motif-containing 27

Symbol

Trim27
Name

tripartite motif-containing 27
Synonyms

Rfp

Feature Type

protein coding gene
IDs

MGI:97904
NCBI Gene: 19720
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr13:21363615-21378894 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 7.67 cM
Mapping Data

6 experiments

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97904	protein coding gene	Chr13:21363570-21378894 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020269	protein coding gene	Chr13:18423508-18438586 (+)
A/J	MGP_AJ_G0020225	protein coding gene	Chr13:18020479-18035543 (+)
AKR/J	MGP_AKRJ_G0020201	protein coding gene	Chr13:18322813-18337881 (+)
BALB/cJ	MGP_BALBcJ_G0020213	protein coding gene	Chr13:18084887-18099951 (+)
C3H/HeJ	MGP_C3HHeJ_G0020014	protein coding gene	Chr13:18426453-18441505 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020657	protein coding gene	Chr13:19076269-19091546 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018264	protein coding gene	Chr13:16409991-16425587 (+)
CAST/EiJ	MGP_CASTEiJ_G0019549	protein coding gene	Chr13:18225157-18246359 (+)
CBA/J	MGP_CBAJ_G0019978	protein coding gene	Chr13:19742242-19757306 (+)
DBA/2J	MGP_DBA2J_G0020099	protein coding gene	Chr13:17667001-17682065 (+)
FVB/NJ	MGP_FVBNJ_G0020081	protein coding gene	Chr13:17330137-17345187 (+)
LP/J	MGP_LPJ_G0020170	protein coding gene	Chr13:18674898-18689956 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020119	protein coding gene	Chr13:20148695-20163757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020685	protein coding gene	Chr13:18154392-18169662 (+)
PWK/PhJ	MGP_PWKPhJ_G0019314	protein coding gene	Chr13:17711364-17726493 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019120	protein coding gene	Chr13:17155774-17169824 (+)
WSB/EiJ	MGP_WSBEiJ_G0019608	protein coding gene	Chr13:18222432-18238636 (+)

Human Ortholog

TRIM27, tripartite motif containing 27

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM27, tripartite motif containing 27
Synonyms

RFP, RNF76
Links

HGNC:9975

NCBI Gene ID: 5987

neXtProt AC: NX_P14373

UniProt: P14373
Chr Location

6p22.1; chr6:28903002-28923988 (-) GRCh38

MGI Vertebrate Homology

Trim27 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: TRIM27
Gene Tree

Trim27

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

11
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Trim27
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit exhibit increased potassium/calcium channel activity and TCR-stimulated calcium influx in Th1 and Th2 CD4 T cells. Mice homozygous for another gene trap allele exhibit decreased incidence of chemically-induced tumors.

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All GO Annotations

69
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

53
cDNA Data

101
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

75
RefSeq

16
UniProt

5
CCDS

CCDS36607.1

Ensembl

ENSMUSG00000021326 (Evidence)
NCBI Gene

19720

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021326	Ensembl Gene Model \| MGI Sequence Detail	15280	C57BL/6J	± kb
transcript	ENSMUST00000021761	Ensembl \| MGI Sequence Detail	4204	Not Applicable
polypeptide	ENSMUSP00000021761	Ensembl \| MGI Sequence Detail	513	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016651 zinc finger protein RFP

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR000315 B-box-type zinc finger

IPR003879 Butyrophylin-like, SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR006574 SPRY-associated

IPR003877 SPRY domain

IPR035791 TRIM27, PRY/SPRY domain

IPR050143 Tripartite motif-containing

IPR020457 Zinc finger, B-box, chordata

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 111

Genomic 1

cDNA 104

Primer pair 5

Other 1

Microarray probesets 5

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MGD-MRK-13851, MGI:2145438

Summaries

All 69

Developmental Gene Expression 4

Gene Ontology 14

Phenotypes 25
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Trim27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118746	Chr13:21363594-21363597 (+)	-19 bp
Tssr118747	Chr13:21363603-21363610 (+)	-8 bp
Tssr118748	Chr13:21363620-21363632 (+)	11 bp
Tssr118749	Chr13:21363637-21363651 (+)	29 bp
Tssr118750	Chr13:21364069-21364112 (+)	476 bp
Tssr118751	Chr13:21364120-21364136 (+)	513 bp
Tssr118752	Chr13:21364153-21364162 (+)	543 bp
Tssr118753	Chr13:21364332-21364346 (+)	724 bp
Tssr118754	Chr13:21364349-21364415 (+)	767 bp
Tssr118755	Chr13:21364560-21364630 (+)	980 bp
Tssr118756	Chr13:21364719-21364774 (+)	1,132 bp
Tssr118757	Chr13:21365120-21365123 (+)	1,507 bp
Tssr118758	Chr13:21365329-21365338 (+)	1,719 bp
Tssr118759	Chr13:21367933-21367954 (+)	4,329 bp
Tssr118760	Chr13:21368032-21368044 (+)	4,423 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24