Rfv1 QTL Detail

Summary

• Symbol
  Rfv1
• Name
  recovery from Friend virus 1
• Synonyms
  Rfv-1

• Feature Type
  QTL
• IDs
  MGI:97905
  NCBI Gene: 110101

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

This QTL controls susceptibility to splenomegaly induced by Friend leukemia virus. Susceptibility to splenomegaly and low recovery rate is associated with H2d haplotype in BALB/c and DBA/2; resistance and high recovery rate is associated with H2b haplotype in C57BL/6. Heterozygotes are intermediate.

Sequences &
Gene Models

• NCBI Gene
  110101

Other
Accession IDs

MGD-MRK-13852, MGD-MRK-13855

References

• Summaries
  All 8
• Earliest
  J:5058 Lilly F, The effect of histocompatibility-2 type on response to Friend leukemia virus in mice. J Exp Med. 1968 Mar 1;127(3):465-73
• Latest
  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20