Rfv2 QTL Detail

Summary

• Symbol
  Rfv2
• Name
  recovery from Friend virus 2
• Synonyms
  Rfv-2

• Feature Type
  QTL
• IDs
  MGI:97906
  NCBI Gene: 110102

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

This QTL influences rate of recovery from splenomegaly induced by Friend virus. Low recovery is associated with d alleles of the H2K-H2I region (A strain), high recovery with b alleles (C57BL/10). Recovery may be mediated in part by the Friend virus-induced immune response of splenic T lymphocytes.

Sequences &
Gene Models

• NCBI Gene
  110102

Other
Accession IDs

MGD-MRK-13853, MGD-MRK-13856

References

• Summaries
  All 4
• Earliest
  J:5969 Chesebro B, et al., Rfv-1 and Rfv-2, two H-2-associated genes that influence recovery from Friend leukemia virus-induced splenomegaly. J Immunol. 1978 Apr;120(4):1081-5
• Latest
  J:1942 Miyazawa M, et al., Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC. J Immunol. 1992 Mar 15;148(6):1964-7