Rgv1 QTL Detail

Summary

• Symbol
  Rgv1
• Name
  resistance to Gross virus 1
• Synonyms
  Rgv-1

• Feature Type
  QTL
• IDs
  MGI:97909
  NCBI Gene: 110064

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

This locus controls resistance to leukemogenesis induced by Gross murine leukemia virus. The allele for susceptibility is associated with H2 haplotypes k, a, and d in C3H, A, and DBA/2 respectively; the allele for resistance is associated with the H2b haplotype of C57BL. Heterozygotes are resistant.

Sequences &
Gene Models

• NCBI Gene
  110064

Other
Accession IDs

MGD-MRK-13859, MGD-MRK-13861

References

• Summaries
  All 4

  Phenotypes 1
• Earliest
  J:5011 Lilly F, The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966 Mar;53(3):529-39
• Latest
  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20