Rmp2 QTL Detail

Summary

• Symbol
  Rmp2
• Name
  resistance to mousepox 2
• Synonyms
  Rmp-2

• Feature Type
  QTL
• IDs
  MGI:97935
  NCBI Gene: 104225

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

This QTL contributes to differences in resistance to mortality from ectromelia virus infection. C57BL/6 is resistant; DBA/2 is susceptible. Some BXD lines lose resistance upon castration inferring a role for gonadal factors, but castrate C57BL/6 remain resistant indicating a redundant mechanism.

Sequences &
Gene Models

• NCBI Gene
  104225

Other
Accession IDs

MGD-MRK-13902, MGD-MRK-13905

References

• Summaries
  All 5

  Phenotypes 1
• Earliest
  J:11032 Brownstein DG, et al., Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality. J Virol. 1991 Apr;65(4):1946-51
• Latest
  J:3240 Brownstein DG, et al., Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3. J Virol. 1992 Dec;66(12):7073-9