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Rmrp Gene Detail
Summary
  • Symbol
    Rmrp
  • Name
    RNA component of mitochondrial RNAase P
  • Synonyms
    Rmrpr, RNase MRP
Location &
Maps
more
  • Sequence Map
    Chr4:43492785-43493059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97937
 RNase MRP RNA gene Chr4:43492783-43493063 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036798
 ribozyme gene Chr4:41610494-41610764 (-)
A/J MGP_AJ_G0036784
 ribozyme gene Chr4:40134681-40134951 (-)
AKR/J MGP_AKRJ_G0036733
 ribozyme gene Chr4:41047025-41047295 (-)
BALB/cJ MGP_BALBcJ_G0036774
 ribozyme gene Chr4:40222152-40222422 (-)
C3H/HeJ MGP_C3HHeJ_G0036463
 ribozyme gene Chr4:41672357-41672627 (-)
C57BL/6NJ MGP_C57BL6NJ_G0037289
 ribozyme gene Chr4:43171939-43172209 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0034356
 ribozyme gene Chr4:37581612-37581882 (-)
CAST/EiJ MGP_CASTEiJ_G0035653
 ribozyme gene Chr4:41176141-41176411 (-)
CBA/J MGP_CBAJ_G0036438
 ribozyme gene Chr4:44475643-44475913 (-)
DBA/2J MGP_DBA2J_G0036612
 ribozyme gene Chr4:40043176-40043446 (-)
FVB/NJ MGP_FVBNJ_G0036566
 ribozyme gene Chr4:39264538-39264808 (-)
LP/J MGP_LPJ_G0036659
 ribozyme gene Chr4:41661844-41662114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036571
 ribozyme gene Chr4:47745975-47746245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0037403
 ribozyme gene Chr4:41240535-41240805 (-)
PWK/PhJ MGP_PWKPhJ_G0035347
 ribozyme gene Chr4:40087415-40087685 (-)
SPRET/EiJ MGP_SPRETEiJ_G0035162
 ribozyme gene Chr4:40827929-40828199 (-)
WSB/EiJ MGP_WSBEiJ_G0035856
 ribozyme gene Chr4:41142287-41142557 (-)



Homology
more
  • Human Ortholog
    RMRP, RNA component of mitochondrial RNA processing endoribonuclease
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RMRP, RNA component of mitochondrial RNA processing endoribonuclease
  • Synonyms
    CHH, NME1, RMRPR, RRP2
  • Links
    NCBI Gene ID: 6023

  • Chr Location
    9p13.3; chr9:35657750-35658019 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RMRP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    5
  • cDNA Data
    1
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      25
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19782 NCBI Gene Model | MGI Sequence Detail 275 C57BL/6J ±  kb
    transcript NR_001460 RefSeq | MGI Sequence Detail 275 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 4
      Genomic 1
      cDNA 1
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-13907, MGD-MRK-13908
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:12493 Hsieh CL, et al., The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human Chromosome 9p and on mouse Chromosome 4. Cytogenet Cell Genet. 1989;51:1016 (Abstr.)
    • Latest
      J:340211 Yang H, et al., Sp1-Induced lncRNA Rmrp Promotes Mesangial Cell Proliferation and Fibrosis in Diabetic Nephropathy by Modulating the miR-1a-3p/JunD Pathway. Front Endocrinol (Lausanne). 2021;12:690784
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory