Rnps1 MGI Mouse Gene Detail - MGI:97960 - RNA binding protein with serine rich domain 1

Symbol

Rnps1
Name

RNA binding protein with serine rich domain 1

Feature Type

protein coding gene
IDs

MGI:97960
NCBI Gene: 19826
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:24633620-24644872 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.39 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

340 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97960	protein coding gene	Chr17:24633539-24644875 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023297	protein coding gene	Chr17:23395671-23406710 (+)
A/J	MGP_AJ_G0023257	protein coding gene	Chr17:22768329-22779294 (+)
AKR/J	MGP_AKRJ_G0023224	protein coding gene	Chr17:22842709-22853579 (+)
BALB/cJ	MGP_BALBcJ_G0023262	protein coding gene	Chr17:22949497-22961595 (+)
C3H/HeJ	MGP_C3HHeJ_G0023022	protein coding gene	Chr17:23192798-23203946 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023706	protein coding gene	Chr17:24424464-24450331 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021182	protein coding gene	Chr17:20234306-20244971 (+)
CAST/EiJ	MGP_CASTEiJ_G0022524	protein coding gene	Chr17:23030402-23041468 (+)
CBA/J	MGP_CBAJ_G0022998	protein coding gene	Chr17:25268894-25283131 (+)
DBA/2J	MGP_DBA2J_G0023127	protein coding gene	Chr17:22349591-22360982 (+)
FVB/NJ	MGP_FVBNJ_G0023097	protein coding gene	Chr17:22070418-22081330 (+)
LP/J	MGP_LPJ_G0023204	protein coding gene	Chr17:23703200-23714176 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023116	protein coding gene	Chr17:24986115-24998114 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023743	protein coding gene	Chr17:23120988-23132068 (+)
PWK/PhJ	MGP_PWKPhJ_G0022273	protein coding gene	Chr17:21105771-21117806 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022092	protein coding gene	Chr17:21147512-21158522 (+)
WSB/EiJ	MGP_WSBEiJ_G0022587	protein coding gene	Chr17:23184979-23195946 (+)

Human Ortholog

RNPS1, RNA binding protein with serine rich domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNPS1, RNA binding protein with serine rich domain 1
Synonyms

E5.1
Links

HGNC:10080

NCBI Gene ID: 10921

neXtProt AC: NX_Q15287

UniProt: Q15287
Chr Location

16p13.3; chr16:2253116-2268397 (-) GRCh38

MGI Vertebrate Homology

Rnps1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNPS1
Gene Tree

Rnps1

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

15
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

119
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnps1

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All Sequences

69
RefSeq

8
UniProt

2
CCDS

CCDS37487.1, CCDS37488.1

Ensembl

ENSMUSG00000034681 (Evidence)
NCBI Gene

19826

			Length	Strain/Species	Flank
genomic	19826	NCBI Gene Model \| MGI Sequence Detail	11253	C57BL/6J	± kb
transcript	NM_001357626	RefSeq \| MGI Sequence Detail	2310	C57BL/6
polypeptide	Q99M28	UniProt \| EBI \| MGI Sequence Detail	305	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014149 RNA-binding protein with serine-rich domain 1

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034201 RNPS1, RNA recognition motif
GlyGen

Q99M28 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 4

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MGD-MRK-13950

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 11
Earliest

J:15705 Schmidt G, et al., Sequence of a complete murine cDNA reflecting an S phase-prevalent transcript encoding a protein with two types of nucleic acid binding motifs. Biochim Biophys Acta. 1993 Nov 16;1216(2):317-20
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Rnps1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143026	Chr17:24633614-24633665 (+)	20 bp
Tssr143027	Chr17:24633887-24633959 (+)	303 bp
Tssr143028	Chr17:24638437-24638441 (+)	4,819 bp
Tssr143029	Chr17:24643444-24643450 (+)	9,827 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24