Rpl12 MGI Mouse Gene Detail - MGI:98002

Symbol

Rpl12
Name

ribosomal protein L12

Feature Type

protein coding gene
IDs

MGI:98002
NCBI Gene: 269261
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:32851724-32854057 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98002	protein coding gene	Chr2:32851571-32855357 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025628	protein coding gene	Chr2:31463713-31468713 (+)
A/J	MGP_AJ_G0025605	protein coding gene	Chr2:30119651-30123791 (+)
AKR/J	MGP_AKRJ_G0025575	protein coding gene	Chr2:31199264-31203251 (+)
BALB/cJ	MGP_BALBcJ_G0025602	protein coding gene	Chr2:30239956-30243742 (+)
C3H/HeJ	MGP_C3HHeJ_G0025362	protein coding gene	Chr2:31082844-31086630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026046	protein coding gene	Chr2:32411559-32415345 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023455	protein coding gene	Chr2:28847431-28851265 (+)
CAST/EiJ	MGP_CASTEiJ_G0024824	protein coding gene	Chr2:31045244-31049233 (+)
CBA/J	MGP_CBAJ_G0025340	protein coding gene	Chr2:33654338-33659202 (+)
DBA/2J	MGP_DBA2J_G0025473	protein coding gene	Chr2:29884206-29887992 (+)
FVB/NJ	MGP_FVBNJ_G0025435	protein coding gene	Chr2:29772304-29778974 (+)
LP/J	MGP_LPJ_G0025559	protein coding gene	Chr2:31347839-31352783 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025466	protein coding gene	Chr2:33249213-33253423 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026104	protein coding gene	Chr2:31073211-31078151 (+)
PWK/PhJ	MGP_PWKPhJ_G0024572	protein coding gene	Chr2:29797781-29801716 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024372	protein coding gene	Chr2:31232410-31237142 (+)
WSB/EiJ	MGP_WSBEiJ_G0024893	protein coding gene	Chr2:31261926-31265748 (+)

Human Ortholog

RPL12, ribosomal protein L12

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL12, ribosomal protein L12
Synonyms

L12, uL11
Links

HGNC:10302

NCBI Gene ID: 6136

neXtProt AC: NX_P30050

UniProt: P30050
Chr Location

9q33.3; chr9:127447674-127451406 (-) GRCh38

MGI Vertebrate Homology

Rpl12 stringent orthology
1 human;1 mouse;4 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL12
Gene Tree

Rpl12

Diseases

1 with human RPL12 associations

				Human Disease	Mouse Models
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

13
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

3
cDNA Data

22
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl12

ZFIN rpl12

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All Sequences

65
RefSeq

2
UniProt

6
CCDS

CCDS15936.1

Ensembl

ENSMUSG00000038900 (Evidence)
NCBI Gene

269261

			Length	Strain/Species	Flank
genomic	269261	NCBI Gene Model \| MGI Sequence Detail	2334	C57BL/6J	± kb
transcript	NM_009076	RefSeq \| MGI Sequence Detail	643	C57BL/6
polypeptide	P35979	UniProt \| EBI \| MGI Sequence Detail	165	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014191 eukaryotic-type large ribosomal subunit protein uL11

(term hierarchy)
PDB

1WIB, 7LS1, 7LS2
InterPro Domains

IPR020785 Large ribosomal subunit protein uL11, conserved site

IPR020783 Large ribosomal subunit protein uL11, C-terminal

IPR036769 Large ribosomal subunit protein uL11, C-terminal domain superfamily

IPR020784 Large ribosomal subunit protein uL11, N-terminal

IPR036796 Large ribosomal subunit protein uL11, N-terminal domain superfamily

IPR000911 Ribosomal protein uL11
GlyGen

P35979 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 8

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MGD-MRK-14025

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 10
Earliest

J:14408 Hou EW, et al., Sequence analysis of mouse cDNAs encoding ribosomal proteins L12 and L18. Gene. 1993 Aug 25;130(2):287-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rpl12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17373	Chr2:32851677-32851704 (+)	-33 bp
Tssr17374	Chr2:32851713-32851726 (+)	-4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24