Rpl27 MGI Mouse Gene Detail - MGI:98036

Symbol

Rpl27
Name

ribosomal protein L27

Feature Type

protein coding gene
IDs

MGI:98036
NCBI Gene: 19942
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:101333124-101336355 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.05 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

221 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98036	protein coding gene	Chr11:101333071-101336422 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019202	protein coding gene	Chr11:104309832-104313586 (+)
A/J	MGP_AJ_G0019170	protein coding gene	Chr11:99918866-99927349 (+)
AKR/J	MGP_AKRJ_G0019139	protein coding gene	Chr11:103028413-103034580 (+)
BALB/cJ	MGP_BALBcJ_G0019144	protein coding gene	Chr11:100415194-100418622 (+)
C3H/HeJ	MGP_C3HHeJ_G0018953	protein coding gene	Chr11:103199290-103205988 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019593	protein coding gene	Chr11:107582608-107588371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017219	protein coding gene	Chr11:97321836-97324985 (+)
CAST/EiJ	MGP_CASTEiJ_G0018507	protein coding gene	Chr11:104181857-104187118 (+)
CBA/J	MGP_CBAJ_G0018922	protein coding gene	Chr11:112012786-112016017 (+)
DBA/2J	MGP_DBA2J_G0019034	protein coding gene	Chr11:99441691-99444922 (+)
FVB/NJ	MGP_FVBNJ_G0019024	protein coding gene	Chr11:98988178-98992246 (+)
LP/J	MGP_LPJ_G0019103	protein coding gene	Chr11:104848715-104852483 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019055	protein coding gene	Chr11:111567196-111570951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019631	protein coding gene	Chr11:103360302-103363595 (+)
PWK/PhJ	MGP_PWKPhJ_G0018270	protein coding gene	Chr11:100508225-100511612 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018062	protein coding gene	Chr11:103083672-103086879 (+)
WSB/EiJ	MGP_WSBEiJ_G0018556	protein coding gene	Chr11:103355610-103358838 (+)

Human Ortholog

RPL27, ribosomal protein L27

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL27, ribosomal protein L27
Synonyms

DBA16, eL27, L27
Links

HGNC:10328

NCBI Gene ID: 6155

neXtProt AC: NX_P61353

UniProt: P61353
Chr Location

17q21.31; chr17:42998273-43002959 (+) GRCh38

MGI Vertebrate Homology

Rpl27 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL27
Gene Tree

Rpl27

Diseases

1 with human RPL27 associations

				Human Disease	Mouse Models
				Diamond-Blackfan anemia 16 IDs Diamond-Blackfan anemia 16 DOID:0111893 OMIM:617408

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

9
Targeted

1
Genomic Mutations

1 involving Rpl27
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

14
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl27

ZFIN rpl27

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All Sequences

50
RefSeq

2
UniProt

4
CCDS

CCDS25470.1

Ensembl

ENSMUSG00000063316 (Evidence)
NCBI Gene

19942

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063316	Ensembl Gene Model \| MGI Sequence Detail	3232	C57BL/6J	± kb
transcript	ENSMUST00000107249	Ensembl \| MGI Sequence Detail	732	Not Applicable
polypeptide	ENSMUSP00000102870	Ensembl \| MGI Sequence Detail	136	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014208 large ribosomal subunit protein eL27

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR005824 KOW

IPR001141 Large ribosomal subunit protein eL27

IPR018262 Large ribosomal subunit protein eL27, conserved site

IPR041991 Large ribosomal subunit protein eL27, KOW domain

IPR038655 Large ribosomal subunit protein eL27 superfamily

IPR008991 Translation protein SH3-like domain superfamily
GlyGen

P61358 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 15

Primer pair 3

Microarray probesets 7

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MGD-MRK-14059

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 9
Earliest

J:8614 Belhumeur P, et al., Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic Acids Res. 1987 Feb 11;15(3):1019-29
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl27:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105109	Chr11:101333115-101333120 (+)	-6 bp
Tssr105110	Chr11:101333193-101333204 (+)	75 bp
Tssr105111	Chr11:101333205-101333221 (+)	89 bp
Tssr105112	Chr11:101333227-101333236 (+)	108 bp
Tssr105113	Chr11:101333238-101333265 (+)	128 bp
Tssr105114	Chr11:101333266-101333294 (+)	156 bp
Tssr105115	Chr11:101333306-101333320 (+)	189 bp
Tssr105116	Chr11:101333348-101333357 (+)	229 bp
Tssr105117	Chr11:101333503-101333510 (+)	383 bp
Tssr105118	Chr11:101333519-101333544 (+)	408 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24