Pdc MGI Mouse Gene Detail - MGI:98090

Symbol

Pdc
Name

phosducin
Synonyms

Pdc, Rpr-1, Rpr1

Feature Type

protein coding gene
IDs

MGI:98090
NCBI Gene: 20028
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:150195168-150209657 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 63.84 cM
Mapping Data

6 experiments

SNPs within 2kb

635 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98090	protein coding gene	Chr1:150195168-150209657 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016574	protein coding gene	Chr1:154968000-154984308 (+)
A/J	MGP_AJ_G0016556	protein coding gene	Chr1:148721386-148735850 (+)
AKR/J	MGP_AKRJ_G0016521	protein coding gene	Chr1:153276223-153292939 (+)
BALB/cJ	MGP_BALBcJ_G0016516	protein coding gene	Chr1:149253960-149268706 (+)
C3H/HeJ	MGP_C3HHeJ_G0016341	protein coding gene	Chr1:153447717-153462177 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016977	protein coding gene	Chr1:160339589-160354350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014686	protein coding gene	Chr1:141085319-141101093 (+)
CAST/EiJ	MGP_CASTEiJ_G0015920	protein coding gene	Chr1:152843552-152861489 (+)
CBA/J	MGP_CBAJ_G0016315	protein coding gene	Chr1:165996767-166014397 (+)
DBA/2J	MGP_DBA2J_G0016421	protein coding gene	Chr1:147772068-147786691 (+)
FVB/NJ	MGP_FVBNJ_G0016419	protein coding gene	Chr1:146198856-146213338 (+)
LP/J	MGP_LPJ_G0016492	protein coding gene	Chr1:156002555-156020133 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016445	protein coding gene	Chr1:173697466-173716888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017013	protein coding gene	Chr1:153074663-153089712 (+)
PWK/PhJ	MGP_PWKPhJ_G0015706	protein coding gene	Chr1:146695489-146710517 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015494	protein coding gene	Chr1:151881899-151899533 (+)
WSB/EiJ	MGP_WSBEiJ_G0015983	protein coding gene	Chr1:153162428-153177546 (+)

Human Ortholog

PDC, phosducin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDC, phosducin
Synonyms

MEKA, PHD, PhLOP, PhLP
Links

HGNC:8759

NCBI Gene ID: 5132

neXtProt AC: NX_P20941

UniProt: P20941
Chr Location

1q31.1; chr1:186443566-186461114 (-) GRCh38

MGI Vertebrate Homology

Pdc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PDC
Gene Tree

Pdc

less

Phenotype Summary

21 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
2 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

2 involving Pdc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.

less

All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

16
cDNA Data

106
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdc

ZFIN pdca

less

All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS15354.1

Ensembl

ENSMUSG00000006007 (Evidence)
NCBI Gene

20028

			Length	Strain/Species	Flank
genomic	20028	NCBI Gene Model \| MGI Sequence Detail	14490	C57BL/6J	± kb
transcript	NM_001159730	RefSeq \| MGI Sequence Detail	1263	ZRU/MplStud
polypeptide	Q9QW08	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000012450 phosducin

(term hierarchy)
InterPro Domains

IPR001200 Phosducin

IPR051499 Phosducin-like regulator

IPR023196 Phosducin, N-terminal domain superfamily

IPR024253 Phosducin, thioredoxin-like domain

IPR036249 Thioredoxin-like superfamily

less

All nucleic 110

Genomic 1

cDNA 108

Primer pair 1

Microarray probesets 4

less

MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116

Summaries

All 46

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 11
Earliest

J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
Latest

J:301112 Maddala R, et al., Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203

TSS for Pdc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9327	Chr1:150195158-150195200 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24