Rps14 MGI Mouse Gene Detail - MGI:98107

Symbol

Rps14
Name

ribosomal protein S14
Synonyms

2600014J02Rik

Feature Type

protein coding gene
IDs

MGI:98107
NCBI Gene: 20044
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:60907668-60911618 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.40 cM
Mapping Data

2 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98107	protein coding gene	Chr18:60880170-60911618 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024467	protein coding gene	Chr18:60604588-60608624 (+)
A/J	MGP_AJ_G0024434	protein coding gene	Chr18:58008139-58012264 (+)
AKR/J	MGP_AKRJ_G0024404	protein coding gene	Chr18:59605276-59609314 (+)
BALB/cJ	MGP_BALBcJ_G0024433	protein coding gene	Chr18:58137286-58141435 (+)
C3H/HeJ	MGP_C3HHeJ_G0024201	protein coding gene	Chr18:59840782-59844818 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024880	protein coding gene	Chr18:62257222-62261258 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022311	protein coding gene	Chr18:57559131-57563229 (+)
CAST/EiJ	MGP_CASTEiJ_G0023674	protein coding gene	Chr18:59705601-59710583 (+)
CBA/J	MGP_CBAJ_G0024171	protein coding gene	Chr18:64274541-64278686 (+)
DBA/2J	MGP_DBA2J_G0024301	protein coding gene	Chr18:57687749-57691785 (+)
FVB/NJ	MGP_FVBNJ_G0024267	protein coding gene	Chr18:57093730-57097771 (+)
LP/J	MGP_LPJ_G0024384	protein coding gene	Chr18:60461569-60465605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024296	protein coding gene	Chr18:65910968-65915021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024927	protein coding gene	Chr18:59805168-59809204 (+)
PWK/PhJ	MGP_PWKPhJ_G0023417	protein coding gene	Chr18:57912315-57916459 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023223	protein coding gene	Chr18:60042767-60046922 (+)
WSB/EiJ	MGP_WSBEiJ_G0023738	protein coding gene	Chr18:59656761-59660797 (+)

Human Ortholog

RPS14, ribosomal protein S14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS14, ribosomal protein S14
Synonyms

EMTB, S14, uS11
Links

HGNC:10387

NCBI Gene ID: 6208

neXtProt AC: NX_P62263

UniProt: P62263
Chr Location

5q33.1; chr5:150442635-150449739 (-) GRCh38

MGI Vertebrate Homology

Rps14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS14
Protein SuperFamily

Ribosomal_S11
Gene Tree

Rps14

Diseases

1 with human RPS14 associations

				Human Disease	Mouse Models
				chromosome 5q deletion syndrome IDs chromosome 5q deletion syndrome DOID:0090016 ICD10CM:D46.7 MESH:C535323 OMIM:153550 ORDO:86841

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

114
Endonuclease-mediated

1
Gene trapped

110
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Conditional heterozygous knockout in hematopoietic cells leads to reduced protein synthesis, resulting in progressive anemia.

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All GO Annotations

44
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

5
cDNA Data

675
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps14

ZFIN rps14

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All Sequences

69
RefSeq

2
UniProt

5
CCDS

CCDS29274.1

Ensembl

ENSMUSG00000024608 (Evidence)
NCBI Gene

20044

			Length	Strain/Species	Flank
genomic	20044	NCBI Gene Model \| MGI Sequence Detail	3951	C57BL/6J	± kb
transcript	NM_020600	RefSeq \| MGI Sequence Detail	606	ZRU/MplStud
polypeptide	P62264	UniProt \| EBI \| MGI Sequence Detail	151	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014255 eukaryotic-type small ribosomal subunit protein uS11

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR001971 Small ribosomal subunit protein uS11

IPR018102 Small ribosomal subunit protein uS11, conserved site

IPR036967 Small ribosomal subunit protein uS11 superfamily
GlyGen

P62264 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 677

cDNA 676

Primer pair 1

Microarray probesets 4

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MGD-MRK-14133, MGI:1914326, MGI:2139854

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 11
Earliest

J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
Latest

J:344838 Sharma S, et al., Uncovering a mammalian neural-specific poly(A) binding protein with unique properties. Genes Dev. 2023 Aug 1;37(15-16):760-777

TSS for Rps14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151323	Chr18:60907686-60907697 (+)	24 bp
Tssr151324	Chr18:60907698-60907735 (+)	49 bp
Tssr151325	Chr18:60907747-60907758 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24