Rrsv QTL Detail

Summary

• Symbol
  Rrsv
• Name
  resistance to Rous sarcoma

• Feature Type
  QTL
• IDs
  MGI:98186
  NCBI Gene: 110025

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 3 alleles in 2 genetic backgrounds
  1 phenotype reference
  

• All Mutations and Alleles
  3
• QTL
  3
• Find Mice (IMSR)
  0 strains or lines available

This H2-linked locus controls susceptibility to Rous sarcoma virus tumorigenesis. The r (resistance) allele occurs in A.SW and B10.D2/oSn; the s allele (susceptibility) occurs in CBA/J, A/WySn and C57BL/10. Heterozygotes are resistant or intermediate.

Sequences &
Gene Models

• NCBI Gene
  110025

Other
Accession IDs

MGD-MRK-14215

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:6009 Whitmore AC, et al., Genetic control of susceptibility of mice to Rous sarcoma virus tumorigenesis. II. Segregation analysis of strain A.SW-associated resistance to primary tumor induction. J Immunol. 1978 Jul;121(1):213-20
• Latest
  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20