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Rxrb Gene Detail
Summary
  • Symbol
    Rxrb
  • Name
    retinoid X receptor beta
  • Synonyms
    H-2RIIBP, Nr2b2, RCoR-1, Rub
  • Feature Type
    protein coding gene
  • IDs
    MGI:98215
    NCBI Gene: 20182
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34250786-34257373 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98215
 protein coding gene Chr17:34250786-34257377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023554
 protein coding gene Chr17:34001251-34007832 (+)
A/J MGP_AJ_G0023518
 protein coding gene Chr17:32823940-32830684 (+)
AKR/J MGP_AKRJ_G0023481
 protein coding gene Chr17:33238057-33244801 (+)
BALB/cJ MGP_BALBcJ_G0023520
 protein coding gene Chr17:32996741-33003484 (+)
C3H/HeJ MGP_C3HHeJ_G0023281
 protein coding gene Chr17:33592530-33599274 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023961
 protein coding gene Chr17:35302730-35309311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021439
 protein coding gene Chr17:30361345-30368150 (+)
CAST/EiJ MGP_CASTEiJ_G0022780
 protein coding gene Chr17:33692785-33699574 (+)
CBA/J MGP_CBAJ_G0023258
 protein coding gene Chr17:36700629-36707373 (+)
DBA/2J MGP_DBA2J_G0023389
 protein coding gene Chr17:32204848-32211591 (+)
FVB/NJ MGP_FVBNJ_G0023353
 protein coding gene Chr17:32074100-32080784 (+)
LP/J MGP_LPJ_G0023464
 protein coding gene Chr17:34284143-34290724 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023376
 protein coding gene Chr17:35747355-35754098 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024003
 protein coding gene Chr17:33579688-33586432 (+)
PWK/PhJ MGP_PWKPhJ_G0022530
 protein coding gene Chr17:31133425-31140194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022345
 protein coding gene Chr17:31531276-31537841 (+)
WSB/EiJ MGP_WSBEiJ_G0022841
 protein coding gene Chr17:33595590-33602326 (+)



Homology
more
  • Human Ortholog
    RXRB, retinoid X receptor beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXRB, retinoid X receptor beta
  • Synonyms
    DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta
  • Links
    NCBI Gene ID: 6257
    neXtProt AC: NX_P28702
    UniProt: P28702

  • Chr Location
    6p21.32; chr6:33193588-33200853 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    43 phenotypes from multigenic genotypes
    4 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice homozygous for a null mutation exhibit partial embryonic and perinatal lethality, and surviving adult males are sterile due to defects in spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    156
  • cDNA Data
    92
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039656 Ensembl Gene Model | MGI Sequence Detail 6588 C57BL/6J ±  kb
    transcript ENSMUST00000044858 Ensembl | MGI Sequence Detail 2627 Not Applicable  
    polypeptide ENSMUSP00000036585 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000014373 retinoic acid receptor RXR-beta
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR021780 Nuclear/hormone receptor activator site AF-1
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR000003 Retinoid X receptor/HNF4
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      P28704 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 14
      cDNA 96
      Primer pair 10
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14265, MGI:2146953
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 46
      Gene Ontology 18
      Phenotypes 33
    • Earliest
      J:19805 Hamada K, et al., H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8289-93
    • Latest
      J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory