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Rxrg Gene Detail
Summary
  • Symbol
    Rxrg
  • Name
    retinoid X receptor gamma
  • Synonyms
    Nr2b3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98216
    NCBI Gene: 20183
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:167425953-167467192 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 74.99 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1421 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98216
 protein coding gene Chr1:167425902-167467192 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016716
 protein coding gene Chr1:173182598-173228979 (+)
A/J MGP_AJ_G0016696
 protein coding gene Chr1:166110992-166152073 (+)
AKR/J MGP_AKRJ_G0016662
 protein coding gene Chr1:171137146-171181977 (+)
BALB/cJ MGP_BALBcJ_G0016657
 protein coding gene Chr1:166597543-166640545 (+)
C3H/HeJ MGP_C3HHeJ_G0016481
 protein coding gene Chr1:171370730-171416500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017118
 protein coding gene Chr1:178958441-179004554 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014827
 protein coding gene Chr1:157946491-157987858 (+)
CAST/EiJ MGP_CASTEiJ_G0016061
 protein coding gene Chr1:170975011-171021522 (+)
CBA/J MGP_CBAJ_G0016456
 protein coding gene Chr1:185345302-185391292 (+)
DBA/2J MGP_DBA2J_G0016562
 protein coding gene Chr1:164951620-164992974 (+)
FVB/NJ MGP_FVBNJ_G0016560
 protein coding gene Chr1:163409915-163454873 (+)
LP/J MGP_LPJ_G0016633
 protein coding gene Chr1:174250116-174291556 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016585
 protein coding gene Chr1:192721860-192765591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017155
 protein coding gene Chr1:171004830-171046668 (+)
PWK/PhJ MGP_PWKPhJ_G0015847
 protein coding gene Chr1:164159304-164202471 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015633
 protein coding gene Chr1:169776786-169818366 (+)
WSB/EiJ MGP_WSBEiJ_G0016123
 protein coding gene Chr1:171111655-171153888 (+)



Homology
more
  • Human Ortholog
    RXRG, retinoid X receptor gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXRG, retinoid X receptor gamma
  • Synonyms
    NR2B3, RXRC, RXR-gamma, RXRgamma
  • Links
    NCBI Gene ID: 6258
    neXtProt AC: NX_P48443
    UniProt: P48443

  • Chr Location
    1q23.3; chr1:165400922-165445355 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RXRG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of exon 2 causes a 25% reduction of neurons in the striatum and may lead to premature death and altered responses to the administration of dopamine antagonists on some genetic backgrounds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1182
  • Tissues
    292
  • cDNA Data
    32
  • Literature Summary
    99
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015843 Ensembl Gene Model | MGI Sequence Detail 41240 C57BL/6J ±  kb
    transcript ENSMUST00000111384 Ensembl | MGI Sequence Detail 1967 Not Applicable  
    polypeptide ENSMUSP00000107015 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014374 retinoic acid receptor RXR-gamma
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR021780 Nuclear/hormone receptor activator site AF-1
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR000003 Retinoid X receptor/HNF4
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      P28705 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 7
      cDNA 36
      Primer pair 13
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14266
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 99
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
    • Latest
      J:342121 Leung AM, et al., A framework to identify functional interactors that contribute to disrupted early retinal development in Vsx2 ocular retardation J mice. Dev Dyn. 2023 Nov;252(11):1338-1362
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory