Saa Complex/Cluster/Region Detail

Summary

• Symbol
  Saa
• Name
  serum amyloid A cluster

• Feature Type
  complex/cluster/region
• IDs
  MGI:98220
  NCBI Gene: 111345
• Cluster Members
  Saal1, Saa3, Saa4 ... (6 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice with loss of the full cluster are viable and fertile with reduced metastatic potential of exogenous tumor cells.

Expression

• Assay Results
  2
• Tissues
  1
• Literature Summary
  1

Tissue x Stage Matrix

Sequences &
Gene Models

• NCBI Gene
  111345

Molecular
Reagents

• All nucleic 4

  Genomic 1

  cDNA 3

Other
Accession IDs

MGD-MRK-14272

References

• Summaries
  All 29

  Developmental Gene Expression 1

  Phenotypes 1
• Earliest
  J:31041 Westermark P, et al., Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils. Scand J Immunol. 1976;5(1-2):31-6
• Latest
  J:355692 Han Y, et al., Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis. Nat Commun. 2023 Aug 24;14(1):4960

Saa Cluster contains:

More Data for these features

Member	Feature Type	Location
Saal1, serum amyloid A-like 1	protein coding gene	Chr7:46336581-46360085 (-)
Saa3, serum amyloid A 3	protein coding gene	Chr7:46361422-46365100 (-)
Saa4, serum amyloid A 4	protein coding gene	Chr7:46377422-46382027 (-)
Saa-ps, serum amyloid A, pseudogene	pseudogene	Chr7:46384112-46385007 (-)
Saa1, serum amyloid A 1	protein coding gene	Chr7:46389921-46392404 (-)
Saa2, serum amyloid A 2	protein coding gene	Chr7:46401257-46403737 (+)