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Saa2 Gene Detail
Summary
  • Symbol
    Saa2
  • Name
    serum amyloid A 2
  • Synonyms
    Saa-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98222
    NCBI Gene: 20209
  • Member of
    Saa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46401257-46403737 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.56 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98222
 protein coding gene Chr7:46401214-46403737 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032270
 protein coding gene Chr7:47134118-47138776 (-)
A/J MGP_AJ_G0032250
 protein coding gene Chr7:46172978-46177672 (+)
AKR/J MGP_AKRJ_G0032186
 protein coding gene Chr7:47462298-47468883 (+)
BALB/cJ MGP_BALBcJ_G0032261
 protein coding gene Chr7:46161616-46165074 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029767
 protein coding gene Chr7:48701556-48704055 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0032050
 protein coding gene Chr7:45637901-45641033 (-)
LP/J MGP_LPJ_G0032178
 protein coding gene Chr7:47849478-47852212 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032088
 protein coding gene Chr7:49671974-49674455 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032768
 protein coding gene Chr7:46672210-46675290 (-)
PWK/PhJ MGP_PWKPhJ_G0031032
 protein coding gene Chr7:39367169-39369021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030865
 protein coding gene Chr7:34693581-34695609 (-)
WSB/EiJ MGP_WSBEiJ_G0031422
 protein coding gene Chr7:47173799-47177466 (-)



Homology
more
  • Human Ortholog
    SAA1, serum amyloid A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAA1, serum amyloid A1
  • Synonyms
    PIG4, SAA, SAA2, TP53I4
  • Links
    NCBI Gene ID: 6288
    neXtProt AC: NX_P0DJI8
    UniProt: P0DJI8

  • Chr Location
    11p15.1; chr11:18266260-18269977 (+)  GRCh38
  • Human Ortholog
    SAA2, serum amyloid A2
  • Synonyms
    SAA, SAA1
  • Links
    NCBI Gene ID: 6289
    neXtProt AC: NX_P0DJI9
    UniProt: P0DJI9

  • Chr Location
    11p15.1; chr11:18238236-18248668 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
The CE/J strain produces a mutant form of Saa2 and is not susceptible to amyloidosis, as are mice of most other inbred strains. M. caroli, M. spretus and M.m. Czech produce variant Saa2 isoforms and M.m. Czech is also reistant to amyloidosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    27
  • cDNA Data
    29
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20209 NCBI Gene Model | MGI Sequence Detail 2481 C57BL/6J ±  kb
transcript NM_001379268 RefSeq | MGI Sequence Detail 825 ZRU/MplStud  
polypeptide P05367 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 7
    cDNA 31
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14274, MGD-MRK-14279, MGI:2142205
References
more
  • Summaries
    All 83
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:6644 Morrow JF, et al., Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718-22
  • Latest
    J:355692 Han Y, et al., Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis. Nat Commun. 2023 Aug 24;14(1):4960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory