Sat1 MGI Mouse Gene Detail - MGI:98233 - spermidine/spermine N1-acetyl transferase 1

Symbol

Sat1
Name

spermidine/spermine N1-acetyl transferase 1

Feature Type

protein coding gene
IDs

MGI:98233
NCBI Gene: 20229
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:153996128-153999345 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 72.38 cM, cytoband F3-F4
Mapping Data

5 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98233	protein coding gene	ChrX:153996128-153999445 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036211	protein coding gene	ChrX:153103851-153107157 (-)
A/J	MGP_AJ_G0036181	protein coding gene	ChrX:152381567-152384909 (-)
AKR/J	MGP_AKRJ_G0036109	protein coding gene	ChrX:157197064-157200494 (-)
BALB/cJ	MGP_BALBcJ_G0036174	protein coding gene	ChrX:150482660-150485969 (-)
C3H/HeJ	MGP_C3HHeJ_G0035880	protein coding gene	ChrX:153435941-153439245 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036696	protein coding gene	ChrX:157561336-157564651 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033516	protein coding gene	ChrX:143962810-143966111 (-)
CAST/EiJ	MGP_CASTEiJ_G0035168	protein coding gene	ChrX:132597582-132601175 (-)
CBA/J	MGP_CBAJ_G0035855	protein coding gene	ChrX:162048955-162052272 (-)
DBA/2J	MGP_DBA2J_G0036021	protein coding gene	ChrX:151385915-151389229 (-)
FVB/NJ	MGP_FVBNJ_G0035951	protein coding gene	ChrX:150496522-150499832 (-)
LP/J	MGP_LPJ_G0036106	protein coding gene	ChrX:154199052-154202366 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035984	protein coding gene	ChrX:170411471-170414783 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036737	protein coding gene	ChrX:152683855-152687195 (-)
PWK/PhJ	MGP_PWKPhJ_G0034866	protein coding gene	ChrX:129584832-129588195 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034687	protein coding gene	ChrX:133048797-133051873 (-)
WSB/EiJ	MGP_WSBEiJ_G0035303	protein coding gene	ChrX:150680810-150684120 (-)

Human Ortholog

SAT1, spermidine/spermine N1-acetyltransferase 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SAT1, spermidine/spermine N1-acetyltransferase 1
Synonyms

DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
Links

HGNC:10540

NCBI Gene ID: 6303

neXtProt AC: NX_P21673

UniProt: P21673
Chr Location

Xp22.11; chrX:23783173-23786210 (+) GRCh38

MGI Vertebrate Homology

Sat1 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: SAT1
Gene Tree

Sat1

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

2
Transgenic

1
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced female fertility, increased percent body fat and total fat pad weight, abnormal liver and white adipose tissue physiology, abnormal aerobic energy metabolism, increased serum leptin levels, and increased weight gain on a high-fat diet.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

117
cDNA Data

14
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sat1

ZFIN sat1a.1, sat1a.2, sat1b

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All Sequences

55
RefSeq

8
UniProt

4
CCDS

CCDS30495.1

Ensembl

ENSMUSG00000025283 (Evidence)
NCBI Gene

20229

			Length	Strain/Species	Flank
genomic	20229	NCBI Gene Model \| MGI Sequence Detail	3218	C57BL/6J	± kb
transcript	NR_189657	RefSeq \| MGI Sequence Detail	1187	C57BL/6
polypeptide	P48026	UniProt \| EBI \| MGI Sequence Detail	171	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014466 diamine acetyltransferase 1

(term hierarchy)
PDB

3BJ7, 3BJ8
EC

2.3.1.57
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR051016 Diverse Substrate Acetyltransferase

IPR000182 GNAT domain

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All nucleic 24

Genomic 5

cDNA 16

Primer pair 3

Microarray probesets 3

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MGD-MRK-14295, MGI:2146776

Summaries

All 87

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 33
Earliest

J:3224 de Meeus A, et al., A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV. Mamm Genome. 1992;3(11):637-43
Latest

J:326958 Sapir T, et al., Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nat Commun. 2022 Jul 21;13(1):4209

TSS for Sat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164435	ChrX:153999440-153999452 (-)	-101 bp
Tssr164434	ChrX:153999370-153999401 (-)	-41 bp
Tssr164433	ChrX:153999334-153999365 (-)	-5 bp
Tssr164432	ChrX:153998676-153998719 (-)	647 bp
Tssr164431	ChrX:153997875-153997878 (-)	1,468 bp
Tssr164430	ChrX:153997100-153997134 (-)	2,228 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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