Scl1 QTL Detail

Summary

• Symbol
  Scl1
• Name
  susceptibility to cutaneous leishmaniasis 1
• Synonyms
  Scl-1

• Feature Type
  QTL
• IDs
  MGI:98243
  NCBI Gene: 107853

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

At this locus, A/J, BALB/cHeA, C3H/He, DBA/1 and C57BL/6 are resistant (r or BALB/cHeA allele). 16 weeks post-infection skin lesions have been resolved. STS/A, SWR and BALB/c are susceptible (s or STS/A allele). 16 weeks post-infection, large non-healinglesions are seen; mice die by 7.5 months.

Sequences &
Gene Models

• NCBI Gene
  107853

Other
Accession IDs

MGD-MRK-14314, MGD-MRK-14316

References

• Summaries
  All 13

  Phenotypes 2
• Earliest
  J:6680 DeTolla LJ, et al., Single gene control of resistance to cutaneous leishmaniasis in mice. Immunogenetics. 1981;14(1-2):29-39
• Latest
  J:145364 Chan WY, et al., The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype. Blood. 2007 Mar 1;109(5):1908-16