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Scp2 Gene Detail
Summary
  • Symbol
    Scp2
  • Name
    sterol carrier protein 2, liver
  • Synonyms
    nonspecific lipid transfer protein, ns-LTP, NSL-TP, SCP-2, SCPx
  • Feature Type
    protein coding gene
  • IDs
    MGI:98254
    NCBI Gene: 20280
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    6 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:107901027-108002168 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.20 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2736 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98254
 protein coding gene Chr4:107901027-108002195 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028548
 protein coding gene Chr4:108758382-108872632 (-)
A/J MGP_AJ_G0028511
 protein coding gene Chr4:104849080-104960799 (-)
AKR/J MGP_AKRJ_G0028458
 protein coding gene Chr4:107433074-107547105 (-)
BALB/cJ MGP_BALBcJ_G0028530
 protein coding gene Chr4:105055555-105160006 (-)
C3H/HeJ MGP_C3HHeJ_G0028244
 protein coding gene Chr4:108170570-108281072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028970
 protein coding gene Chr4:112658614-112781806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026261
 protein coding gene Chr4:100154061-100260078 (-)
CAST/EiJ MGP_CASTEiJ_G0027680
 protein coding gene Chr4:106015365-106125568 (-)
CBA/J MGP_CBAJ_G0028213
 protein coding gene Chr4:116321423-116445364 (-)
DBA/2J MGP_DBA2J_G0028361
 protein coding gene Chr4:104474900-104578685 (-)
FVB/NJ MGP_FVBNJ_G0028329
 protein coding gene Chr4:103344900-103452870 (-)
LP/J MGP_LPJ_G0028462
 protein coding gene Chr4:108958127-109078734 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028355
 protein coding gene Chr4:121568896-121680061 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029006
 protein coding gene Chr4:107676609-107778157 (-)
PWK/PhJ MGP_PWKPhJ_G0027406
 protein coding gene Chr4:102731429-102835073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027230
 protein coding gene Chr4:105044280-105156757 (-)
WSB/EiJ MGP_WSBEiJ_G0027761
 protein coding gene Chr4:107862370-107970815 (-)



Homology
more
  • Human Ortholog
    SCP2, sterol carrier protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCP2, sterol carrier protein 2
  • Synonyms
    NLTP, NSL-TP, SCOX, SCP-2, SCP-CHI, SCP-X, SCPX
  • Links
    NCBI Gene ID: 6342
    neXtProt AC: NX_P22307
    UniProt: P22307

  • Chr Location
    1p32.3; chr1:52927276-53051698 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene exhibit altered lipid levels and both males and females are sensitive to phytol-rich diets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    118
  • cDNA Data
    382
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20280 NCBI Gene Model | MGI Sequence Detail 101142 C57BL/6J ±  kb
    transcript NM_011327 RefSeq | MGI Sequence Detail 2664 ZRU/MplStud  
    polypeptide P32020 UniProt | EBI | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 392
      Genomic 4
      cDNA 384
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14327, MGI:2140147, MGI:2140148, MGI:2140647, MGI:2140673
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:11174 Moncecchi D, et al., cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2. J Biol Chem. 1991 May 25;266(15):9885-92
    • Latest
      J:338452 Wang D, et al., MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters. Nat Commun. 2023 Jul 21;14(1):4404
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory