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Msr1 Gene Detail
Summary
  • Symbol
    Msr1
  • Name
    macrophage scavenger receptor 1
  • Synonyms
    MRS-A, MSR-A, Scara1, Scvr, SR-AI, SR-AII
  • Feature Type
    protein coding gene
  • IDs
    MGI:98257
    NCBI Gene: 20288
  • Alliance
    gene page
  • Transcription Start Sites
    49 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:40034726-40095714 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2004 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98257
 protein coding gene Chr8:39996284-40095790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033549
 protein coding gene Chr8:38357084-38423975 (-)
A/J MGP_AJ_G0033529
 protein coding gene Chr8:36902760-36966844 (-)
AKR/J MGP_AKRJ_G0033453
 protein coding gene Chr8:37995245-38061889 (-)
BALB/cJ MGP_BALBcJ_G0033525
 protein coding gene Chr8:36990919-37053540 (-)
C3H/HeJ MGP_C3HHeJ_G0033237
 protein coding gene Chr8:38390555-38454501 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034041
 protein coding gene Chr8:39804896-39871039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030990
 protein coding gene Chr8:33576369-33635763 (-)
CAST/EiJ MGP_CASTEiJ_G0032565
 protein coding gene Chr8:37876354-37947662 (-)
CBA/J MGP_CBAJ_G0033215
 protein coding gene Chr8:41445757-41524651 (-)
DBA/2J MGP_DBA2J_G0033368
 protein coding gene Chr8:36757213-36818932 (-)
FVB/NJ MGP_FVBNJ_G0033313
 protein coding gene Chr8:36342811-36406402 (-)
LP/J MGP_LPJ_G0033458
 protein coding gene Chr8:38388643-38455071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033355
 protein coding gene Chr8:41213910-41300813 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034060
 protein coding gene Chr8:38156981-38225583 (-)
PWK/PhJ MGP_PWKPhJ_G0032274
 protein coding gene Chr8:36309126-36370509 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032106
 protein coding gene Chr8:37361135-37434511 (-)
WSB/EiJ MGP_WSBEiJ_G0032680
 protein coding gene Chr8:38376837-38441380 (-)



Homology
more
  • Human Ortholog
    MSR1, macrophage scavenger receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSR1, macrophage scavenger receptor 1
  • Synonyms
    CD204, phSR1, phSR2, SCARA1, SR-A, SRA, SR-AI, SR-AII, SR-AIII
  • Links
    NCBI Gene ID: 4481
    neXtProt AC: NX_P21757
    UniProt: P21757

  • Chr Location
    8p22; chr8:16107878-16567490 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MSR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    146 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal uptake and degradation of acetylated low density lipoproteins by macrophages, increased interleukin-12 secretion in response to CpG oligodeoxynucleotide administration, and increased bacterial and viral infection induced morbidity/mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    58
  • cDNA Data
    25
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025044 Ensembl Gene Model | MGI Sequence Detail 60989 C57BL/6J ±  kb
transcript ENSMUST00000026021 Ensembl | MGI Sequence Detail 1424 Not Applicable  
polypeptide ENSMUSP00000026021 Ensembl | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 2
    cDNA 26
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14331
References
more
  • Summaries
    All 217
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 146
  • Earliest
    J:10839 Freeman M, et al., An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8810-4
  • Latest
    J:353785 Wei C, et al., Macrophage Scavenger Receptor 1 attenuates ischemic white matter injury via HRH1-mediated microglial phagocytosis. Neurosci Lett. 2024 Oct 15;841:137952
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory