Ccl5 MGI Mouse Gene Detail - MGI:98262 - C-C motif chemokine ligand 5

Symbol

Ccl5
Name

C-C motif chemokine ligand 5
Synonyms

MuRantes, RANTES, Scya5, SISd, TCP228

Feature Type

protein coding gene
IDs

MGI:98262
NCBI Gene: 20304
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:83416604-83421344 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.66 cM
Mapping Data

7 experiments

SNPs within 2kb

285 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98262	protein coding gene	Chr11:83416604-83421344 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018852	protein coding gene	Chr11:84859467-84864213 (-)
A/J	MGP_AJ_G0018819	protein coding gene	Chr11:81635597-81640343 (-)
AKR/J	MGP_AKRJ_G0018789	protein coding gene	Chr11:84076504-84081258 (-)
BALB/cJ	MGP_BALBcJ_G0018792	protein coding gene	Chr11:82048224-82052964 (-)
C3H/HeJ	MGP_C3HHeJ_G0018606	protein coding gene	Chr11:84123470-84128216 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019244	protein coding gene	Chr11:87455568-87460312 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016878	protein coding gene	Chr11:78765545-78769900 (-)
CAST/EiJ	MGP_CASTEiJ_G0018161	protein coding gene	Chr11:84707303-84711972 (-)
CBA/J	MGP_CBAJ_G0018577	protein coding gene	Chr11:91231089-91235835 (-)
DBA/2J	MGP_DBA2J_G0018685	protein coding gene	Chr11:81236144-81240898 (-)
FVB/NJ	MGP_FVBNJ_G0018674	protein coding gene	Chr11:80722341-80727085 (-)
LP/J	MGP_LPJ_G0018755	protein coding gene	Chr11:85419435-85424181 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018701	protein coding gene	Chr11:91400751-91405499 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019284	protein coding gene	Chr11:84339823-84344576 (-)
PWK/PhJ	MGP_PWKPhJ_G0017930	protein coding gene	Chr11:81996423-82001292 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017722	protein coding gene	Chr11:83879070-83883757 (-)
WSB/EiJ	MGP_WSBEiJ_G0018212	protein coding gene	Chr11:84201241-84206003 (-)

Human Ortholog

CCL5, C-C motif chemokine ligand 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL5, C-C motif chemokine ligand 5
Synonyms

D17S136E, eoCP, RANTES, SCYA5, SISd, SIS-delta, TCP228
Links

HGNC:10632

NCBI Gene ID: 6352

neXtProt AC: NX_P13501

UniProt: P13501
Chr Location

17q12; chr17:35871491-35880793 (-) GRCh38

MGI Vertebrate Homology

Ccl5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCL5
Gene Tree

Ccl5

Diseases

10 with human CCL5 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				hepatitis B IDs hepatitis B DOID:2043 DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 NCI:C3097 UMLS_CUI:C0019163
				hepatitis C IDs hepatitis C DOID:1883 DOID:12430 DOID:12432 DOID:2049 EFO:0003047 ICD10CM:B19.20 ICD9CM:070.7 MESH:D006526 NCI:C3098 UMLS_CUI:C0019196
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				pancreatitis IDs pancreatitis DOID:4989 EFO:0000278 ICD10CM:K85.9 MESH:D010195 NCI:C3306 OMIM:167800 UMLS_CUI:C0030305
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				severe acute respiratory syndrome IDs severe acute respiratory syndrome DOID:2945 ICD10CM:J12.81 ICD9CM:079.82 MESH:D045169 NCI:C85064 UMLS_CUI:C1175175
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

6
Transgenic

3
Genomic Mutations

2 involving Ccl5
Find Mice (IMSR)

11 strains or lines available

Homozygous mutation of this gene results in decreased ear and footpad swelling following injection with DHT. T cell proliferative response is also impaired in mutant mice.

less

All GO Annotations

133
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

61
cDNA Data

21
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccl5

less

All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS36254.1

Ensembl

ENSMUSG00000035042 (Evidence)
NCBI Gene

20304

			Length	Strain/Species	Flank
genomic	20304	NCBI Gene Model \| MGI Sequence Detail	4741	C57BL/6J	± kb
transcript	NM_013653	RefSeq \| MGI Sequence Detail	579	ZRU/MplStud
polypeptide	P30882	UniProt \| EBI \| MGI Sequence Detail	91	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000002094 C-C motif chemokine 5

(term hierarchy)
PDB

5YAM
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

less

All nucleic 28

Genomic 3

cDNA 21

Primer pair 4

Microarray probesets 3

less

MGD-MRK-14336

Summaries

All 183

Developmental Gene Expression 15

Gene Ontology 16

Phenotypes 59
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346467 Liao X, et al., Adipose stem cells control obesity-induced T cell infiltration into adipose tissue. Cell Rep. 2024 Mar 15;43(3):113963

TSS for Ccl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109676	Chr11:83421476-83421490 (-)	-139 bp
Tssr109675	Chr11:83421331-83421359 (-)	-1 bp
Tssr109674	Chr11:83421306-83421326 (-)	28 bp
Tssr109673	Chr11:83420047-83420073 (-)	1,284 bp
Tssr109672	Chr11:83420009-83420029 (-)	1,325 bp
Tssr109671	Chr11:83419925-83419943 (-)	1,410 bp
Tssr109670	Chr11:83418488-83418500 (-)	2,850 bp
Tssr109669	Chr11:83417329-83417341 (-)	4,009 bp
Tssr109668	Chr11:83416851-83416896 (-)	4,470 bp
Tssr109667	Chr11:83416820-83416847 (-)	4,510 bp
Tssr109666	Chr11:83416744-83416819 (-)	4,562 bp
Tssr109665	Chr11:83416705-83416734 (-)	4,624 bp
Tssr109664	Chr11:83416672-83416701 (-)	4,657 bp
Tssr109663	Chr11:83416647-83416655 (-)	4,693 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24