Ccl6 MGI Mouse Gene Detail - MGI:98263 - C-C motif chemokine ligand 6

Symbol

Ccl6
Name

C-C motif chemokine ligand 6
Synonyms

c10, MRP-1, Scya6

Feature Type

protein coding gene
IDs

MGI:98263
NCBI Gene: 20305
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:83478712-83483913 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.85 cM
Mapping Data

11 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98263	protein coding gene	Chr11:83478708-83483913 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018854	protein coding gene	Chr11:84933109-84938344 (-)
A/J	MGP_AJ_G0018821	protein coding gene	Chr11:81699909-81705229 (-)
AKR/J	MGP_AKRJ_G0018791	protein coding gene	Chr11:84136879-84142080 (-)
BALB/cJ	MGP_BALBcJ_G0018794	protein coding gene	Chr11:82116380-82121587 (-)
C3H/HeJ	MGP_C3HHeJ_G0018608	protein coding gene	Chr11:84193333-84198568 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019246	protein coding gene	Chr11:87533203-87538392 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016880	protein coding gene	Chr11:78819175-78825280 (-)
CAST/EiJ	MGP_CASTEiJ_G0018163	protein coding gene	Chr11:84772187-84777530 (-)
CBA/J	MGP_CBAJ_G0018579	protein coding gene	Chr11:91289432-91294667 (-)
DBA/2J	MGP_DBA2J_G0018687	protein coding gene	Chr11:81298691-81304022 (-)
FVB/NJ	MGP_FVBNJ_G0018676	protein coding gene	Chr11:80782254-80787449 (-)
LP/J	MGP_LPJ_G0018757	protein coding gene	Chr11:85480463-85485690 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018703	protein coding gene	Chr11:91468590-91473803 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019286	protein coding gene	Chr11:84409742-84414954 (-)
PWK/PhJ	MGP_PWKPhJ_G0017932	protein coding gene	Chr11:82056599-82061860 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017724	protein coding gene	Chr11:83943913-83947919 (-)
WSB/EiJ	MGP_WSBEiJ_G0018214	protein coding gene	Chr11:84267243-84272478 (-)

Human Ortholog

CCL15, C-C motif chemokine ligand 15

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL15, C-C motif chemokine ligand 15
Synonyms

HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1D, MIP-1 delta, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15
Links

HGNC:10613

NCBI Gene ID: 6359

neXtProt AC: NX_Q16663

UniProt: Q16663
Chr Location

17q12; chr17:35996440-36001553 (-) GRCh38

Human Ortholog

CCL23, C-C motif chemokine ligand 23
Synonyms

Ckb-8, CKb8, Ckb-8-1, CK-BETA-8, hmrp-2a, MIP-3, MIP3, MPIF-1, SCYA23
Links

HGNC:10622

NCBI Gene ID: 6368

neXtProt AC: NX_P55773

UniProt: P55773
Chr Location

17q12; chr17:36013056-36017972 (-) GRCh38

MGI Vertebrate Homology

Ccl6 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCL15, CCL23
Gene Tree

Ccl6

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References

1 with disease annotations

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Phenotype Summary

19 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Transgenic

4
Genomic Mutations

3 involving Ccl6
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

11
cDNA Data

50
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

1
CCDS

CCDS25171.1

Ensembl

ENSMUSG00000018927 (Evidence)
NCBI Gene

20305

			Length	Strain/Species	Flank
genomic	20305	NCBI Gene Model \| MGI Sequence Detail	5202	C57BL/6J	± kb
transcript	NM_009139	RefSeq \| MGI Sequence Detail	1436	ZRU/MplStud
polypeptide	P27784	UniProt \| EBI \| MGI Sequence Detail	116	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006166 C-C motif chemokine 6

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

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All nucleic 58

Genomic 6

cDNA 50

Primer pair 1

Other 1

Microarray probesets 6

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MGD-MRK-14337

Summaries

All 65

Developmental Gene Expression 6

Diseases 1

Gene Ontology 6

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344232 Chandra R, et al., Gut mucosal cells transfer alpha-synuclein to the vagus nerve. JCI Insight. 2023;8(23):e172192

TSS for Ccl6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109715	Chr11:83483807-83483825 (-)	97 bp
Tssr109714	Chr11:83483378-83483396 (-)	526 bp
Tssr109713	Chr11:83481453-83481469 (-)	2,452 bp
Tssr109712	Chr11:83480601-83480629 (-)	3,298 bp
Tssr109711	Chr11:83480167-83480244 (-)	3,707 bp
Tssr109710	Chr11:83479741-83479754 (-)	4,165 bp
Tssr109709	Chr11:83479606-83479650 (-)	4,285 bp
Tssr109708	Chr11:83479535-83479538 (-)	4,376 bp
Tssr109707	Chr11:83479434-83479437 (-)	4,477 bp
Tssr109706	Chr11:83479101-83479119 (-)	4,803 bp
Tssr109705	Chr11:83478982-83478993 (-)	4,925 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24