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Sds Gene Detail
Summary
  • Symbol
    Sds
  • Name
    serine dehydratase
  • Synonyms
    SDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:98270
    NCBI Gene: 231691
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120614612-120621997 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98270
 protein coding gene Chr5:120614591-120621997 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030003
 protein coding gene Chr5:123832899-123840276 (+)
A/J MGP_AJ_G0029967
 protein coding gene Chr5:118720745-118728122 (+)
AKR/J MGP_AKRJ_G0029906
 protein coding gene Chr5:122550461-122557846 (+)
BALB/cJ MGP_BALBcJ_G0029978
 protein coding gene Chr5:120137037-120144416 (+)
C3H/HeJ MGP_C3HHeJ_G0029698
 protein coding gene Chr5:123081206-123088586 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030433
 protein coding gene Chr5:128493068-128500468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027659
 protein coding gene Chr5:113428732-113435966 (+)
CAST/EiJ MGP_CASTEiJ_G0029107
 protein coding gene Chr5:122207517-122214808 (+)
CBA/J MGP_CBAJ_G0029666
 protein coding gene Chr5:133483322-133490714 (+)
DBA/2J MGP_DBA2J_G0029816
 protein coding gene Chr5:118805457-118812835 (+)
FVB/NJ MGP_FVBNJ_G0029772
 protein coding gene Chr5:117725055-117732432 (+)
LP/J MGP_LPJ_G0029904
 protein coding gene Chr5:124301387-124308764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029803
 protein coding gene Chr5:137453770-137461147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030474
 protein coding gene Chr5:122123627-122131004 (+)
PWK/PhJ MGP_PWKPhJ_G0028820
 protein coding gene Chr5:117564487-117571940 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028659
 protein coding gene Chr5:119785077-119792391 (+)
WSB/EiJ MGP_WSBEiJ_G0029182
 protein coding gene Chr5:122713378-122720721 (+)



Homology
more
  • Human Ortholog
    SDS, serine dehydratase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDS, serine dehydratase
  • Synonyms
    hSDH, SDH
  • Links
    NCBI Gene ID: 10993
    neXtProt AC: NX_P20132
    UniProt: P20132

  • Chr Location
    12q24.13; chr12:113392445-113426301 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Sds
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    24 strains or lines available
Sds is the serine dehydratase structural gene. Albino region deletions profoundly affect development and expression of some gluconeogenic enzymes, including Sds. In these deletion mice, Sds is expressed normally on the constitutive level, but fails to develop hormone-inducible expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    115
  • cDNA Data
    53
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231691 NCBI Gene Model | MGI Sequence Detail 7386 C57BL/6J ±  kb
transcript NM_145565 RefSeq | MGI Sequence Detail 1164 FVB/N  
polypeptide Q8VBT2 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014570 L-serine dehydratase/L-threonine deaminase
    (term hierarchy)
  • EC
    4.3.1.17, 4.3.1.19
  • InterPro Domains
    IPR050147 Serine/Threonine Dehydratase
    IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site
    IPR001926 Tryptophan synthase beta chain-like, PALP domain
    IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily
  • GlyGen
    Q8VBT2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 61
    Genomic 5
    cDNA 53
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14347
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345466 Benneyworth MA, et al., Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function. Neuropsychopharmacology. 2012 Oct;37(11):2496-504
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory