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Sele Gene Detail
Summary
  • Symbol
    Sele
  • Name
    selectin, endothelial cell
  • Synonyms
    CD62E, Elam, E-selectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98278
    NCBI Gene: 20339
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163875773-163885246 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.35 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98278
 protein coding gene Chr1:163867200-163886056 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016677
 protein coding gene Chr1:169460608-169470147 (+)
A/J MGP_AJ_G0016658
 protein coding gene Chr1:162557575-162567008 (+)
AKR/J MGP_AKRJ_G0016624
 protein coding gene Chr1:167489348-167498763 (+)
BALB/cJ MGP_BALBcJ_G0016619
 protein coding gene Chr1:163058715-163068131 (+)
C3H/HeJ MGP_C3HHeJ_G0016443
 protein coding gene Chr1:167671572-167680997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017080
 protein coding gene Chr1:175163461-175172898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014789
 protein coding gene Chr1:154543464-154552853 (+)
CAST/EiJ MGP_CASTEiJ_G0016023
 protein coding gene Chr1:167310959-167321546 (+)
CBA/J MGP_CBAJ_G0016418
 protein coding gene Chr1:181393218-181402658 (+)
DBA/2J MGP_DBA2J_G0016524
 protein coding gene Chr1:161452869-161462352 (+)
FVB/NJ MGP_FVBNJ_G0016522
 protein coding gene Chr1:159904430-159913867 (+)
LP/J MGP_LPJ_G0016595
 protein coding gene Chr1:170542279-170551728 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016547
 protein coding gene Chr1:188905304-188919578 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017116
 protein coding gene Chr1:167316123-167325521 (+)
PWK/PhJ MGP_PWKPhJ_G0015809
 protein coding gene Chr1:160642526-160652289 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015596
 protein coding gene Chr1:166193223-166202785 (+)
WSB/EiJ MGP_WSBEiJ_G0016085
 protein coding gene Chr1:167481086-167490500 (+)



Homology
more
  • Human Ortholog
    SELE, selectin E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELE, selectin E
  • Synonyms
    CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin-e
  • Links
    NCBI Gene ID: 6401
    neXtProt AC: NX_P16581
    UniProt: P16581

  • Chr Location
    1q24.2; chr1:169722640-169764705 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human SELE associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 9 genetic backgrounds
    54 phenotypes from multigenic genotypes
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    48
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026582 Ensembl Gene Model | MGI Sequence Detail 9474 C57BL/6J ±  kb
    transcript ENSMUST00000027874 Ensembl | MGI Sequence Detail 2942 Not Applicable  
    polypeptide ENSMUSP00000027874 Ensembl | MGI Sequence Detail 612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 4
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14357, MGD-MRK-9356
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 108
    • Earliest
      J:10574 Watson ML, et al., Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990 Jul 1;172(1):263-72
    • Latest
      J:349202 Genduso S, et al., Tumor cell integrin beta4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo. J Hematol Oncol. 2023 Mar 17;16(1):23
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory