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Snai1 Gene Detail
Summary
  • Symbol
    Snai1
  • Name
    snail family zinc finger 1
  • Synonyms
    Sna, Sna1, Snail, Snail1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98330
    NCBI Gene: 20613
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167380115-167384734 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98330
 protein coding gene Chr2:167380115-167384734 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026915
 protein coding gene Chr2:173277825-173284225 (+)
A/J MGP_AJ_G0026882
 protein coding gene Chr2:166140150-166144758 (+)
AKR/J MGP_AKRJ_G0026853
 protein coding gene Chr2:171098539-171103145 (+)
BALB/cJ MGP_BALBcJ_G0026891
 protein coding gene Chr2:166499419-166504937 (+)
C3H/HeJ MGP_C3HHeJ_G0026633
 protein coding gene Chr2:171465460-171474029 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027338
 protein coding gene Chr2:178331128-178337248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024709
 protein coding gene Chr2:159459015-159463735 (+)
CAST/EiJ MGP_CASTEiJ_G0026091
 protein coding gene Chr2:171927783-171934024 (+)
CBA/J MGP_CBAJ_G0026610
 protein coding gene Chr2:184876463-184882984 (+)
DBA/2J MGP_DBA2J_G0026748
 protein coding gene Chr2:165259297-165263903 (+)
FVB/NJ MGP_FVBNJ_G0026714
 protein coding gene Chr2:163783304-163788165 (+)
LP/J MGP_LPJ_G0026849
 protein coding gene Chr2:173288098-173293983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026733
 protein coding gene Chr2:188255863-188260568 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027395
 protein coding gene Chr2:171028421-171035972 (+)
PWK/PhJ MGP_PWKPhJ_G0025828
 protein coding gene Chr2:164923115-164927955 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025629
 protein coding gene Chr2:169965577-169970171 (+)
WSB/EiJ MGP_WSBEiJ_G0026164
 protein coding gene Chr2:171938276-171942923 (+)



Homology
more
  • Human Ortholog
    SNAI1, snail family transcriptional repressor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNAI1, snail family transcriptional repressor 1
  • Synonyms
    dJ710H13.1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1
  • Links
    NCBI Gene ID: 6615
    neXtProt AC: NX_O95863
    UniProt: O95863

  • Chr Location
    20q13.13; chr20:49982980-49988886 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Snai1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 7 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality by E8.5, reduced size, and abnormal mesoderm development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1675
  • Tissues
    490
  • cDNA Data
    42
  • Literature Summary
    225
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20613 NCBI Gene Model | MGI Sequence Detail 4620 C57BL/6J ±  kb
    transcript NM_011427 RefSeq | MGI Sequence Detail 1633 ZRU/MplStud  
    polypeptide Q02085 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 44
      Primer pair 13
      Other 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14460, MGI:2138858
    References
    more
    • Summaries
      All 350
      Developmental Gene Expression 225
      Diseases 2
      Gene Ontology 20
      Phenotypes 53
    • Earliest
      J:3088 Nieto MA, et al., Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene. Development. 1992 Sep;116(1):227-37
    • Latest
      J:353564 Hoffmann H, et al., Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer. Oncogene. 2024 Aug;43(35):2661-2676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory