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Snap25 Gene Detail
Summary
  • Symbol
    Snap25
  • Name
    synaptosomal-associated protein 25
  • Synonyms
    Bdr, GENA 70, SNAP-25, sp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98331
    NCBI Gene: 20614
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:136555373-136624348 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 67.56 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1626 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98331
 protein coding gene Chr2:136555359-136624348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026559
 protein coding gene Chr2:140504095-140575446 (+)
A/J MGP_AJ_G0026523
 protein coding gene Chr2:134808184-134877650 (+)
AKR/J MGP_AKRJ_G0026497
 protein coding gene Chr2:138675097-138744092 (+)
BALB/cJ MGP_BALBcJ_G0026535
 protein coding gene Chr2:135185303-135254181 (+)
C3H/HeJ MGP_C3HHeJ_G0026278
 protein coding gene Chr2:139125246-139194769 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026980
 protein coding gene Chr2:144722519-144793058 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024357
 protein coding gene Chr2:129348873-129419949 (+)
CAST/EiJ MGP_CASTEiJ_G0025739
 protein coding gene Chr2:139500948-139574896 (+)
CBA/J MGP_CBAJ_G0026258
 protein coding gene Chr2:150116810-150187442 (+)
DBA/2J MGP_DBA2J_G0026392
 protein coding gene Chr2:134166365-134235515 (+)
FVB/NJ MGP_FVBNJ_G0026356
 protein coding gene Chr2:132748333-132817203 (+)
LP/J MGP_LPJ_G0026496
 protein coding gene Chr2:140672848-140743996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026376
 protein coding gene Chr2:153940436-154010748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027035
 protein coding gene Chr2:138680033-138752218 (+)
PWK/PhJ MGP_PWKPhJ_G0025475
 protein coding gene Chr2:133789006-133859021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025277
 protein coding gene Chr2:137778404-137855380 (+)
WSB/EiJ MGP_WSBEiJ_G0025813
 protein coding gene Chr2:139593623-139663249 (+)



Homology
more
  • Human Ortholog
    SNAP25, synaptosome associated protein 25
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNAP25, synaptosome associated protein 25
  • Synonyms
    bA416N4.2, CMS18, dJ1068F16.2, RIC-4, RIC4, SEC9, SNAP, SNAP-25, SUP
  • Links
    NCBI Gene ID: 6616
    neXtProt AC: NX_P60880
    UniProt: P60880

  • Chr Location
    20p12.2; chr20:10172395-10308258 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Snap25 mouse models; 2 with human SNAP25 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 8 alleles in 11 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are small size, blotchy in appearance, have dilated vascular channels, and brain defects, lack spontaneous or reflexive movement and evoked neurotransmitter release at E18.5, and die at birth. An ENU-induced mutant displays neurological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    43
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    79
  • cDNA Data
    16
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027273 Ensembl Gene Model | MGI Sequence Detail 68976 C57BL/6J ±  kb
    transcript ENSMUST00000028727 Ensembl | MGI Sequence Detail 2116 Not Applicable  
    polypeptide ENSMUSP00000028727 Ensembl | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14461, MGI:1861990
    References
    more
    • Summaries
      All 295
      Developmental Gene Expression 67
      Diseases 4
      Gene Ontology 43
      Phenotypes 137
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358170 Raveendran VA, et al., SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons. iScience. 2024 Nov 15;27(11):111156
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory