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Snrnp70 Gene Detail
Summary
  • Symbol
    Snrnp70
  • Name
    small nuclear ribonucleoprotein 70 (U1)
  • Synonyms
    2700022N21Rik, 3200002N22Rik, Rnulp70, Srnp70, U1-70
  • Feature Type
    protein coding gene
  • IDs
    MGI:98341
    NCBI Gene: 20637
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45025877-45045166 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98341
 protein coding gene Chr7:45025877-45045177 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032217
 protein coding gene Chr7:45625974-45645156 (-)
A/J MGP_AJ_G0032196
 protein coding gene Chr7:44762156-44781237 (-)
AKR/J MGP_AKRJ_G0032132
 protein coding gene Chr7:45991664-46010646 (-)
BALB/cJ MGP_BALBcJ_G0032208
 protein coding gene Chr7:44751491-44770760 (-)
C3H/HeJ MGP_C3HHeJ_G0031924
 protein coding gene Chr7:46481979-46501128 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032700
 protein coding gene Chr7:47895531-47917749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029714
 protein coding gene Chr7:47312546-47333796 (-)
CAST/EiJ MGP_CASTEiJ_G0031252
 protein coding gene Chr7:37886930-37910582 (-)
CBA/J MGP_CBAJ_G0031888
 protein coding gene Chr7:49481036-49500101 (-)
DBA/2J MGP_DBA2J_G0032046
 protein coding gene Chr7:44425640-44445069 (-)
FVB/NJ MGP_FVBNJ_G0031997
 protein coding gene Chr7:44204444-44226483 (-)
LP/J MGP_LPJ_G0032124
 protein coding gene Chr7:46330494-46349813 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032034
 protein coding gene Chr7:48179666-48200963 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032716
 protein coding gene Chr7:45210033-45230897 (-)
PWK/PhJ MGP_PWKPhJ_G0030975
 protein coding gene Chr7:37798315-37820539 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030812
 protein coding gene Chr7:33217984-33245075 (-)
WSB/EiJ MGP_WSBEiJ_G0031369
 protein coding gene Chr7:45704913-45724076 (-)



Homology
more
  • Human Ortholog
    SNRNP70, small nuclear ribonucleoprotein U1 subunit 70
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNRNP70, small nuclear ribonucleoprotein U1 subunit 70
  • Synonyms
    RNPU1Z, RPU1, Snp1, SNRP70, U1-70K, U170K, U1AP, U1RNP
  • Links
    NCBI Gene ID: 6625
    neXtProt AC: NX_P08621
    UniProt: P08621

  • Chr Location
    19q13.33; chr19:49085419-49108605 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SNRNP70 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation and lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    60
  • cDNA Data
    170
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063511 Ensembl Gene Model | MGI Sequence Detail 19290 C57BL/6J ±  kb
transcript ENSMUST00000074575 Ensembl | MGI Sequence Detail 1735 Not Applicable  
polypeptide ENSMUSP00000074160 Ensembl | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000015338 U1 small nuclear ribonucleoprotein 70 kDa
    (term hierarchy)
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR034143 snRNP70, RNA recognition motif
    IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal
    IPR051183 U1 snRNP 70 kDa and U11/U12 snRNP 35 kDa
Molecular
Reagents
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  • All nucleic 177
    Genomic 2
    cDNA 173
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14003, MGD-MRK-14471, MGD-MRK-14602, MGI:1913569, MGI:1919842, MGI:2141914, MGI:2142381
References
more
  • Summaries
    All 56
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:23362 Query CC, et al., A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. Cell. 1987 Oct 23;51(2):211-20
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory