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Snrpb Gene Detail
Summary
  • Symbol
    Snrpb
  • Name
    small nuclear ribonucleoprotein B
  • Synonyms
    SM11, SM-B, SMB, SNRNP-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:98342
    NCBI Gene: 20638
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130013555-130021323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98342
 protein coding gene Chr2:130013555-130031184 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026495
 protein coding gene Chr2:133613857-133621853 (-)
A/J MGP_AJ_G0026459
 protein coding gene Chr2:128208837-128216826 (-)
AKR/J MGP_AKRJ_G0026434
 protein coding gene Chr2:131874752-131882748 (-)
BALB/cJ MGP_BALBcJ_G0026471
 protein coding gene Chr2:128564875-128572834 (-)
C3H/HeJ MGP_C3HHeJ_G0026214
 protein coding gene Chr2:132332378-132340337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026916
 protein coding gene Chr2:137752186-137760175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024293
 protein coding gene Chr2:122953443-122961606 (-)
CAST/EiJ MGP_CASTEiJ_G0025675
 protein coding gene Chr2:132585458-132593699 (-)
CBA/J MGP_CBAJ_G0026194
 protein coding gene Chr2:142853200-142861159 (-)
DBA/2J MGP_DBA2J_G0026328
 protein coding gene Chr2:127596481-127604470 (-)
FVB/NJ MGP_FVBNJ_G0026292
 protein coding gene Chr2:126217962-126225921 (-)
LP/J MGP_LPJ_G0026433
 protein coding gene Chr2:133867732-133875728 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026312
 protein coding gene Chr2:146713634-146721630 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026971
 protein coding gene Chr2:131856275-131864271 (-)
PWK/PhJ MGP_PWKPhJ_G0025411
 protein coding gene Chr2:127150903-127158862 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025213
 protein coding gene Chr2:130977298-130985268 (-)
WSB/EiJ MGP_WSBEiJ_G0025749
 protein coding gene Chr2:132782623-132790622 (-)



Homology
more
  • Human Ortholog
    SNRPB, small nuclear ribonucleoprotein polypeptides B and B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNRPB, small nuclear ribonucleoprotein polypeptides B and B1
  • Synonyms
    CCMS, COD, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, SNRPB1
  • Links
    NCBI Gene ID: 6628
    neXtProt AC: NX_P14678
    UniProt: P14678

  • Chr Location
    20p13; chr20:2461634-2470853 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Snrpb mouse models; 2 with human SNRPB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for loss of expression in all cells die before birth. Mice heterozygous for loss of expression in neural crest cells die perinatally with extensive craniofacial and nervous system defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    31
  • cDNA Data
    342
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027404 Ensembl Gene Model | MGI Sequence Detail 7769 C57BL/6J ±  kb
    transcript ENSMUST00000103199 Ensembl | MGI Sequence Detail 1161 Not Applicable  
    polypeptide ENSMUSP00000099488 Ensembl | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 345
      Genomic 1
      cDNA 344

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14472, MGI:2139173
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:333803 Turner BRH, et al., Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos. Dev Dyn. 2023 Feb;252(2):276-293
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory