About   Help   FAQ
Sos2 Gene Detail
Summary
  • Symbol
    Sos2
  • Name
    SOS Ras/Rho guanine nucleotide exchange factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98355
    NCBI Gene: 20663
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69630536-69728626 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.93 cM, cytoband C3-D
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2277 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98355
 protein coding gene Chr12:69630535-69728626 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019798
 protein coding gene Chr12:69284457-69389945 (-)
A/J MGP_AJ_G0019756
 protein coding gene Chr12:66696942-66795673 (-)
AKR/J MGP_AKRJ_G0019732
 protein coding gene Chr12:68695531-68794137 (-)
BALB/cJ MGP_BALBcJ_G0019736
 protein coding gene Chr12:67153168-67253394 (-)
C3H/HeJ MGP_C3HHeJ_G0019542
 protein coding gene Chr12:69158798-69261318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020188
 protein coding gene Chr12:71501760-71611362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017808
 protein coding gene Chr12:64239066-64335197 (-)
CAST/EiJ MGP_CASTEiJ_G0019093
 protein coding gene Chr12:63913561-64013895 (-)
CBA/J MGP_CBAJ_G0019511
 protein coding gene Chr12:74126957-74244709 (-)
DBA/2J MGP_DBA2J_G0019627
 protein coding gene Chr12:66610208-66707703 (-)
FVB/NJ MGP_FVBNJ_G0019614
 protein coding gene Chr12:65506593-65608003 (-)
LP/J MGP_LPJ_G0019699
 protein coding gene Chr12:69227674-69332491 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019653
 protein coding gene Chr12:77456358-77564297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020223
 protein coding gene Chr12:68164140-68268794 (-)
PWK/PhJ MGP_PWKPhJ_G0018858
 protein coding gene Chr12:60881651-60976006 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018653
 protein coding gene Chr12:62550504-62644579 (-)
WSB/EiJ MGP_WSBEiJ_G0019144
 protein coding gene Chr12:68801659-68903274 (-)



Homology
more
  • Human Ortholog
    SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2
  • Synonyms
    NS9, SOS-2
  • Links
    NCBI Gene ID: 6655
    neXtProt AC: NX_Q07890
    UniProt: Q07890

  • Chr Location
    14q21.3; chr14:50117130-50231882 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SOS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal embryonic and adult histopathology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    25
  • cDNA Data
    66
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034801 Ensembl Gene Model | MGI Sequence Detail 98091 C57BL/6J ±  kb
transcript ENSMUST00000183277 Ensembl | MGI Sequence Detail 4512 Not Applicable  
polypeptide ENSMUSP00000138793 Ensembl | MGI Sequence Detail 1333 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015414 son of sevenless homolog 2
    (term hierarchy)
  • PDB
    1GBR
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR009072 Histone-fold
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
less
  • All nucleic 67
    Genomic 1
    cDNA 66

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14490
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 14
  • Earliest
    J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
  • Latest
    J:327859 Gomez C, et al., Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia. Cancers (Basel). 2022 Aug 11;14(16)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory