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Sox12 Gene Detail
Summary
  • Symbol
    Sox12
  • Name
    SRY (sex determining region Y)-box 12
  • Synonyms
    2010205A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98360
    NCBI Gene: 20667
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152235531-152239966 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98360
 protein coding gene Chr2:152235531-152239983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026658
 protein coding gene Chr2:156928943-156933395 (-)
A/J MGP_AJ_G0026624
 protein coding gene Chr2:150680993-150685564 (-)
AKR/J MGP_AKRJ_G0026594
 protein coding gene Chr2:155076315-155080767 (-)
BALB/cJ MGP_BALBcJ_G0026633
 protein coding gene Chr2:150988921-150993373 (-)
C3H/HeJ MGP_C3HHeJ_G0026376
 protein coding gene Chr2:155461808-155466260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027082
 protein coding gene Chr2:161515582-161520034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024453
 protein coding gene Chr2:144268233-144272640 (-)
CAST/EiJ MGP_CASTEiJ_G0025837
 protein coding gene Chr2:155695886-155700350 (-)
CBA/J MGP_CBAJ_G0026354
 protein coding gene Chr2:167424008-167428460 (-)
DBA/2J MGP_DBA2J_G0026490
 protein coding gene Chr2:149894636-149899088 (-)
FVB/NJ MGP_FVBNJ_G0026456
 protein coding gene Chr2:148337362-148341679 (-)
LP/J MGP_LPJ_G0026594
 protein coding gene Chr2:157092605-157097057 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026477
 protein coding gene Chr2:171533623-171538194 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027138
 protein coding gene Chr2:154960012-154964464 (-)
PWK/PhJ MGP_PWKPhJ_G0025571
 protein coding gene Chr2:149412793-149417364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025374
 protein coding gene Chr2:153785312-153789773 (-)
WSB/EiJ MGP_WSBEiJ_G0025907
 protein coding gene Chr2:155883132-155887584 (-)



Homology
more
  • Human Ortholog
    SOX12, SRY-box transcription factor 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX12, SRY-box transcription factor 12
  • Synonyms
    SOX22
  • Links
    NCBI Gene ID: 6666
    neXtProt AC: NX_O15370
    UniProt: O15370

  • Chr Location
    20p13; chr20:325552-330224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    15 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Sox12
  • Find Mice (IMSR)
    8 strains or lines available
Mice homozygous for a null allele exhibit no phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    113
  • cDNA Data
    62
  • Literature Summary
    27
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20667 NCBI Gene Model | MGI Sequence Detail 4436 C57BL/6J ±  kb
transcript NM_011438 RefSeq | MGI Sequence Detail 4436 C57BL/6  
polypeptide Q04890 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 62
    Primer pair 6
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14499, MGI:1917235
References
more
  • Summaries
    All 63
    Developmental Gene Expression 27
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326693 Angelozzi M, et al., Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory