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Sox6 Gene Detail
Summary
  • Symbol
    Sox6
  • Name
    SRY (sex determining region Y)-box 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:98368
    NCBI Gene: 20679
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:115070107-115638031 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 61.29 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10461 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98368
 protein coding gene Chr7:115070107-115639186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032887
 protein coding gene Chr7:119192787-119768549 (-)
A/J MGP_AJ_G0032870
 protein coding gene Chr7:116183426-116751225 (-)
AKR/J MGP_AKRJ_G0032802
 protein coding gene Chr7:119122260-119680861 (-)
BALB/cJ MGP_BALBcJ_G0032875
 protein coding gene Chr7:115890604-116463247 (-)
C3H/HeJ MGP_C3HHeJ_G0032585
 protein coding gene Chr7:119078726-119642521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033381
 protein coding gene Chr7:123958946-124560942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030353
 protein coding gene Chr7:117705046-118265068 (-)
CAST/EiJ MGP_CASTEiJ_G0031913
 protein coding gene Chr7:110741670-111330369 (-)
CBA/J MGP_CBAJ_G0032558
 protein coding gene Chr7:128087262-128685688 (-)
DBA/2J MGP_DBA2J_G0032710
 protein coding gene Chr7:114250356-114808349 (-)
FVB/NJ MGP_FVBNJ_G0032663
 protein coding gene Chr7:114087904-114648552 (-)
LP/J MGP_LPJ_G0032804
 protein coding gene Chr7:120676875-121249977 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032695
 protein coding gene Chr7:129663490-130272841 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033401
 protein coding gene Chr7:118111510-118696506 (-)
PWK/PhJ MGP_PWKPhJ_G0031621
 protein coding gene Chr7:107123330-107682406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031468
 protein coding gene Chr7:104841414-105414148 (-)
WSB/EiJ MGP_WSBEiJ_G0032026
 protein coding gene Chr7:118984170-119569585 (-)



Homology
more
  • Human Ortholog
    SOX6, SRY-box transcription factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX6, SRY-box transcription factor 6
  • Synonyms
    HSSOX6, SOXD, TOLCAS
  • Links
    NCBI Gene ID: 55553
    neXtProt AC: NX_P35712
    UniProt: P35712

  • Chr Location
    11p15.2; chr11:15966449-16739591 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SOX6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit cardioskeletal myopathy, cardiac blockage, delayed growth, and early postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1138
  • Tissues
    218
  • cDNA Data
    24
  • Literature Summary
    112
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051910 Ensembl Gene Model | MGI Sequence Detail 567925 C57BL/6J ±  kb
    transcript ENSMUST00000206369 Ensembl | MGI Sequence Detail 2863 Not Applicable  
    polypeptide ENSMUSP00000145931 Ensembl | MGI Sequence Detail 828 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 2
      cDNA 27
      Primer pair 11
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14507, MGI:2142080
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 112
      Gene Ontology 23
      Phenotypes 44
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory