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Sox7 Gene Detail
Summary
  • Symbol
    Sox7
  • Name
    SRY (sex determining region Y)-box 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98369
    NCBI Gene: 20680
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64181155-64188181 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.34 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98369
 protein coding gene Chr14:64181122-64188181 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021466
 protein coding gene Chr14:58497271-58504331 (+)
A/J MGP_AJ_G0021425
 protein coding gene Chr14:57155776-57162832 (+)
AKR/J MGP_AKRJ_G0021401
 protein coding gene Chr14:59178949-59186005 (+)
BALB/cJ MGP_BALBcJ_G0021431
 protein coding gene Chr14:57113388-57120446 (+)
C3H/HeJ MGP_C3HHeJ_G0021208
 protein coding gene Chr14:58799621-58806681 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021870
 protein coding gene Chr14:61238383-61245441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019410
 protein coding gene Chr14:55091317-55098315 (+)
CAST/EiJ MGP_CASTEiJ_G0020725
 protein coding gene Chr14:55256394-55276397 (+)
CBA/J MGP_CBAJ_G0021175
 protein coding gene Chr14:63083893-63090951 (+)
DBA/2J MGP_DBA2J_G0021298
 protein coding gene Chr14:56829524-56836584 (+)
FVB/NJ MGP_FVBNJ_G0021277
 protein coding gene Chr14:56213633-56220679 (+)
LP/J MGP_LPJ_G0021373
 protein coding gene Chr14:59531917-59538977 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021306
 protein coding gene Chr14:62275335-62282393 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021893
 protein coding gene Chr14:58337229-58344287 (+)
PWK/PhJ MGP_PWKPhJ_G0020469
 protein coding gene Chr14:53506995-53547548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020302
 protein coding gene Chr14:54302417-54321573 (+)
WSB/EiJ MGP_WSBEiJ_G0020778
 protein coding gene Chr14:58655869-58662922 (+)



Homology
more
  • Human Ortholog
    SOX7, SRY-box transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX7, SRY-box transcription factor 7
  • Links
    NCBI Gene ID: 83595
    neXtProt AC: NX_Q9BT81
    UniProt: Q9BT81

  • Chr Location
    8p23.1; chr8:10723768-10730511 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sox7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele exhibit growth retardation, abnormal vitelline vascular remodeling, pericardial edema, hypocellular atrioventricular endocardial cushions, and death during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital diaphragmatic hernias.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    204
  • cDNA Data
    22
  • Literature Summary
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
    transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified  
    polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 23
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14508
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 54
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:355327 Blucher RO, et al., VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. BMC Biol. 2024 Oct 1;22(1):222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory