Sp1 MGI Mouse Gene Detail - MGI:98372 - trans-acting transcription factor 1

Symbol

Sp1
Name

trans-acting transcription factor 1
Synonyms

1110003E12Rik, Sp1-1

Feature Type

protein coding gene
IDs

MGI:98372
NCBI Gene: 20683
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:102314751-102344839 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.55 cM
Mapping Data

6 experiments

SNPs within 2kb

614 from dbSNP Build 142
Strain Annotations

18
RFLP

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98372	protein coding gene	Chr15:102314578-102344839 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022412	protein coding gene	Chr15:104585064-104622678 (+)
A/J	MGP_AJ_G0022374	protein coding gene	Chr15:100466734-100498150 (+)
AKR/J	MGP_AKRJ_G0022349	protein coding gene	Chr15:103513614-103546706 (+)
BALB/cJ	MGP_BALBcJ_G0022378	protein coding gene	Chr15:100520304-100555440 (+)
C3H/HeJ	MGP_C3HHeJ_G0022145	protein coding gene	Chr15:103587220-103619280 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022827	protein coding gene	Chr15:108467407-108506261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020350	protein coding gene	Chr15:96242610-96274357 (+)
CAST/EiJ	MGP_CASTEiJ_G0021671	protein coding gene	Chr15:104465596-104497285 (+)
CBA/J	MGP_CBAJ_G0022114	protein coding gene	Chr15:112285804-112318170 (+)
DBA/2J	MGP_DBA2J_G0022245	protein coding gene	Chr15:99754746-99785250 (+)
FVB/NJ	MGP_FVBNJ_G0022221	protein coding gene	Chr15:98816889-98846276 (+)
LP/J	MGP_LPJ_G0022314	protein coding gene	Chr15:104736983-104768868 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022243	protein coding gene	Chr15:115841697-115876377 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022839	protein coding gene	Chr15:103534866-103578674 (+)
PWK/PhJ	MGP_PWKPhJ_G0021411	protein coding gene	Chr15:99915142-99945011 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021243	protein coding gene	Chr15:103387904-103422366 (+)
WSB/EiJ	MGP_WSBEiJ_G0021721	protein coding gene	Chr15:104170580-104207706 (+)

Human Ortholog

SP1, Sp1 transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SP1, Sp1 transcription factor
Links

HGNC:11205

NCBI Gene ID: 6667

neXtProt AC: NX_P08047

UniProt: P08047
Chr Location

12q13.13; chr12:53380176-53416446 (+) GRCh38

MGI Vertebrate Homology

Sp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SP1
Gene Tree

Sp1

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
25 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

257
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

246
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Sp1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

164 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display reduced embryo size and die during organogenesis with a broad range of developmental defects. Heterozygous null mice are viable but slightly growth retarded, may lack one or both eyes, and show a decreased erythroid progenitor cell number in fetal liver cultures.

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All GO Annotations

90
GO References

39

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1083
Tissues

229
cDNA Data

180
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sp1

ZFIN sp1

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All Sequences

65
RefSeq

4
UniProt

7
CCDS

CCDS37229.1

Ensembl

ENSMUSG00000001280 (Evidence)
NCBI Gene

20683

			Length	Strain/Species	Flank
genomic	20683	NCBI Gene Model \| MGI Sequence Detail	30089	C57BL/6J	± kb
transcript	NM_013672	RefSeq \| MGI Sequence Detail	7818	C57BL/6
polypeptide	O89090	UniProt \| EBI \| MGI Sequence Detail	784	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000000133 transcription factor Sp1

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

O89090 7 sites, 1 O-linked glycan (6 sites)

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All nucleic 192

Genomic 2

cDNA 181

Primer pair 8

Other 1

Microarray probesets 7

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MGD-MRK-14512, MGI:1915735, MGI:2146073, MGI:3034478

Summaries

All 231

Developmental Gene Expression 39

Diseases 1

Gene Ontology 39

Phenotypes 42
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:350494 Perrin S, et al., MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells. Sci Transl Med. 2024 Jun 26;16(753):eadj1597

TSS for Sp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133397	Chr15:102314704-102314768 (+)	-15 bp
Tssr4739	Chr15:102314809-102314833 (+)	70 bp
Tssr133398	Chr15:102315402-102315412 (+)	656 bp
Tssr133399	Chr15:102315579-102315582 (+)	830 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24