Spp1 MGI Mouse Gene Detail - MGI:98389 - secreted phosphoprotein 1

Symbol

Spp1
Name

secreted phosphoprotein 1
Synonyms

2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1

Feature Type

protein coding gene
IDs

MGI:98389
NCBI Gene: 20750
Alliance

gene page
Transcription Start Sites

27 TSS

Sequence Map

Chr5:104582984-104588916 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 50.68 cM
Mapping Data

35 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98389	protein coding gene	Chr5:104582977-104588919 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029814	protein coding gene	Chr5:106110130-106116062 (+)
A/J	MGP_AJ_G0029778	protein coding gene	Chr5:102126319-102132248 (+)
AKR/J	MGP_AKRJ_G0029726	protein coding gene	Chr5:105442303-105448235 (+)
BALB/cJ	MGP_BALBcJ_G0029790	protein coding gene	Chr5:103194303-103200232 (+)
C3H/HeJ	MGP_C3HHeJ_G0029512	protein coding gene	Chr5:105834893-105840893 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030245	protein coding gene	Chr5:110463135-110469067 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027480	protein coding gene	Chr5:97240302-97246343 (+)
CAST/EiJ	MGP_CASTEiJ_G0028924	protein coding gene	Chr5:104546074-104552138 (+)
CBA/J	MGP_CBAJ_G0029483	protein coding gene	Chr5:114308698-114314630 (+)
DBA/2J	MGP_DBA2J_G0029627	protein coding gene	Chr5:102330060-102335990 (+)
FVB/NJ	MGP_FVBNJ_G0029586	protein coding gene	Chr5:101107481-101113403 (+)
LP/J	MGP_LPJ_G0029715	protein coding gene	Chr5:106710675-106716607 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029615	protein coding gene	Chr5:119219157-119225433 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030278	protein coding gene	Chr5:104954131-104960060 (+)
PWK/PhJ	MGP_PWKPhJ_G0028641	protein coding gene	Chr5:100773718-100779670 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028477	protein coding gene	Chr5:102615552-102621487 (+)
WSB/EiJ	MGP_WSBEiJ_G0029002	protein coding gene	Chr5:105339218-105346031 (+)

Human Ortholog

SPP1, secreted phosphoprotein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPP1, secreted phosphoprotein 1
Synonyms

BNSP, BSPI, ETA-1, OPN
Links

HGNC:11255

NCBI Gene ID: 6696

neXtProt AC: NX_P10451

UniProt: P10451
Chr Location

4q22.1; chr4:87975667-87983532 (+) GRCh38

MGI Vertebrate Homology

Spp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPP1
Gene Tree

Spp1

Diseases

14 with human SPP1 associations

				Human Disease	Mouse Models
				biliary atresia IDs biliary atresia DOID:13608 ICD10CM:Q44.2 ICD9CM_2006:751.61 ICD9CM:751.61 MESH:D001656 NCI:C34421 OMIM:210500 ORDO:30391 UMLS_CUI:C0005411
				coronary restenosis IDs coronary restenosis DOID:4247 MESH:D023903 UMLS_CUI:C0948480
				disease of cellular proliferation IDs disease of cellular proliferation DOID:14566 DOID:0000818
				hepatitis IDs hepatitis DOID:2237 DOID:12352 DOID:14551 DOID:1706 DOID:1707 DOID:2238 ICD10CM:K73.9 ICD9CM:570 ICD9CM:571.4 ICD9CM:571.40 ICD9CM:571.41 MESH:D006521 NCI:C82978 UMLS_CUI:C0001308 UMLS_CUI:C0019189 UMLS_CUI:C0149519
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				melanoma IDs melanoma DOID:1909 EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 UMLS_CUI:C0025202
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

102 phenotypes from 6 alleles in 28 genetic backgrounds
48 phenotypes from multigenic genotypes
2 images
294 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Chemically induced (other)

1
Endonuclease-mediated

11
Gene trapped

19
QTL

2
Radiation induced

1
Spontaneous

1
Targeted

12
Transgenic

1
Genomic Mutations

3 involving Spp1
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Two alleles determine natural resistance/susceptibility to the lethal effects of the Gilliam strain of Rickettsia tsutsugamushi. Mice homozygous for a knock-out allele exhibit abnormal osteoclast physiology, macrophage recruitment, wound healing, response to injury, and inflammatory response.

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All GO Annotations

48
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1441
Tissues

344
cDNA Data

1278
Literature Summary

286

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

91
RefSeq

10
UniProt

11
CCDS

CCDS19486.1, CCDS57367.1

Ensembl

ENSMUSG00000029304 (Evidence)
NCBI Gene

20750

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029304	Ensembl Gene Model \| MGI Sequence Detail	5933	C57BL/6J	± kb
transcript	ENSMUST00000086833	Ensembl \| MGI Sequence Detail	1411	Not Applicable
polypeptide	ENSMUSP00000084043	Ensembl \| MGI Sequence Detail	295	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000015561 osteopontin

(term hierarchy)
InterPro Domains

IPR002038 Osteopontin

IPR019841 Osteopontin, conserved site
GlyGen

P10923 5 sites

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All nucleic 1320

Genomic 2

cDNA 1286

Primer pair 14

Other 18

Microarray probesets 3

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MGD-MRK-13036, MGD-MRK-13037, MGD-MRK-1359, MGD-MRK-13878, MGD-MRK-14544, MGD-MRK-14545, MGD-MRK-9656, MGI:2140792, MGI:2140963

Summaries

All 759

Developmental Gene Expression 286

Gene Ontology 15

Phenotypes 294
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:353623 Almubarak A, et al., FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. Development. 2024 Aug 15;151(16)

TSS for Spp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47635	Chr5:104582164-104582203 (+)	-800 bp
Tssr47636	Chr5:104582276-104582288 (+)	-702 bp
Tssr47637	Chr5:104582390-104582418 (+)	-580 bp
Tssr47638	Chr5:104582571-104582605 (+)	-396 bp
Tssr47639	Chr5:104582978-104582994 (+)	2 bp
Tssr47640	Chr5:104584234-104584253 (+)	1,260 bp
Tssr47641	Chr5:104584401-104584415 (+)	1,424 bp
Tssr47642	Chr5:104585511-104585522 (+)	2,533 bp
Tssr47643	Chr5:104587121-104587159 (+)	4,156 bp
Tssr47644	Chr5:104587160-104587177 (+)	4,185 bp
Tssr47645	Chr5:104587178-104587243 (+)	4,227 bp
Tssr47646	Chr5:104587261-104587360 (+)	4,327 bp
Tssr47647	Chr5:104587364-104587385 (+)	4,391 bp
Tssr47648	Chr5:104588083-104588093 (+)	5,104 bp
Tssr1569	Chr5:104588093-104588124 (+)	5,125 bp
Tssr47649	Chr5:104588129-104588184 (+)	5,173 bp
Tssr47650	Chr5:104588201-104588253 (+)	5,243 bp
Tssr47651	Chr5:104588255-104588284 (+)	5,286 bp
Tssr47652	Chr5:104588360-104588393 (+)	5,393 bp
Tssr47653	Chr5:104588437-104588442 (+)	5,456 bp
Tssr47654	Chr5:104588444-104588454 (+)	5,465 bp
Tssr47655	Chr5:104588456-104588475 (+)	5,482 bp
Tssr47656	Chr5:104588487-104588498 (+)	5,509 bp
Tssr47657	Chr5:104588542-104588569 (+)	5,572 bp
Tssr47658	Chr5:104588574-104588586 (+)	5,596 bp
Tssr47659	Chr5:104588621-104588638 (+)	5,646 bp
Tssr47660	Chr5:104588640-104588655 (+)	5,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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