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Spp1 Gene Detail
Summary
  • Symbol
    Spp1
  • Name
    secreted phosphoprotein 1
  • Synonyms
    2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98389
    NCBI Gene: 20750
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104582984-104588916 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98389
 protein coding gene Chr5:104582977-104588919 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029814
 protein coding gene Chr5:106110130-106116062 (+)
A/J MGP_AJ_G0029778
 protein coding gene Chr5:102126319-102132248 (+)
AKR/J MGP_AKRJ_G0029726
 protein coding gene Chr5:105442303-105448235 (+)
BALB/cJ MGP_BALBcJ_G0029790
 protein coding gene Chr5:103194303-103200232 (+)
C3H/HeJ MGP_C3HHeJ_G0029512
 protein coding gene Chr5:105834893-105840893 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030245
 protein coding gene Chr5:110463135-110469067 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027480
 protein coding gene Chr5:97240302-97246343 (+)
CAST/EiJ MGP_CASTEiJ_G0028924
 protein coding gene Chr5:104546074-104552138 (+)
CBA/J MGP_CBAJ_G0029483
 protein coding gene Chr5:114308698-114314630 (+)
DBA/2J MGP_DBA2J_G0029627
 protein coding gene Chr5:102330060-102335990 (+)
FVB/NJ MGP_FVBNJ_G0029586
 protein coding gene Chr5:101107481-101113403 (+)
LP/J MGP_LPJ_G0029715
 protein coding gene Chr5:106710675-106716607 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029615
 protein coding gene Chr5:119219157-119225433 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030278
 protein coding gene Chr5:104954131-104960060 (+)
PWK/PhJ MGP_PWKPhJ_G0028641
 protein coding gene Chr5:100773718-100779670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028477
 protein coding gene Chr5:102615552-102621487 (+)
WSB/EiJ MGP_WSBEiJ_G0029002
 protein coding gene Chr5:105339218-105346031 (+)



Homology
more
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
  • Synonyms
    BNSP, BSPI, ETA-1, OPN
  • Links
    NCBI Gene ID: 6696
    neXtProt AC: NX_P10451
    UniProt: P10451

  • Chr Location
    4q22.1; chr4:87975667-87983532 (+)  GRCh38
Human Diseases
more
  • Diseases
    14 with human SPP1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 6 alleles in 28 genetic backgrounds
    48 phenotypes from multigenic genotypes
    2 images
    295 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Two alleles determine natural resistance/susceptibility to the lethal effects of the Gilliam strain of Rickettsia tsutsugamushi. Mice homozygous for a knock-out allele exhibit abnormal osteoclast physiology, macrophage recruitment, wound healing, response to injury, and inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    48
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1441
  • Tissues
    344
  • cDNA Data
    1278
  • Literature Summary
    286
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029304 Ensembl Gene Model | MGI Sequence Detail 5933 C57BL/6J ±  kb
    transcript ENSMUST00000086833 Ensembl | MGI Sequence Detail 1411 Not Applicable  
    polypeptide ENSMUSP00000084043 Ensembl | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1320
      Genomic 2
      cDNA 1286
      Primer pair 14
      Other 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13036, MGD-MRK-13037, MGD-MRK-1359, MGD-MRK-13878, MGD-MRK-14544, MGD-MRK-14545, MGD-MRK-9656, MGI:2140792, MGI:2140963
    References
    more
    • Summaries
      All 760
      Developmental Gene Expression 286
      Gene Ontology 15
      Phenotypes 295
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:359131 Datta A, et al., Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. PLoS One. 2024;19(10):e0313027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory