Sr1 Gene Detail

Summary

• Symbol
  Sr1
• Name
  spectrotype regulation
• Synonyms
  Sr-1

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:98396
  NCBI Gene: 104244
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 14, Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

This locus regulates isoelectric focusing (IEF) pattern of the IgG anti-inulin antibodies produced in mice bearing the a haplotype of Igh. The a allele in BALB/c determines a single spectrotype by IEF. The b allele of C57BL/6, when carried by Igha-bearing mice, determines a more complex pattern.

Sequences &
Gene Models

• NCBI Gene
  104244

Other
Accession IDs

MGD-MRK-14554, MGD-MRK-14555

References

• Summaries
  All 4
• Earliest
  J:6314 Stein KE, et al., Regulation of the anti-inulin antibody response by a nonallotype-linked gene. J Exp Med. 1980 May 1;151(5):1089-102
• Latest
  J:76969 Jones Tiffany L, et al., The Sr1 gene that controls diversity of the anti-inulin antibody response maps to mouse chromosome 14. Immunogenetics. 2003 May;55(2):80-6