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Sts Gene Detail
Summary
  • Symbol
    Sts
  • Name
    steroid sulfatase
  • Synonyms
    ArsC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98438
    NCBI Gene: 20905
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:168909030-169014924 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome XY, Syntenic
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • Strain Annotations
    1
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98438
 protein coding gene ChrX:168856332-169015037 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    STS, steroid sulfatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STS, steroid sulfatase
  • Synonyms
    ARSC, ARSC1, ASC, ES, SSDD, XLI
  • Links
    NCBI Gene ID: 412
    neXtProt AC: NX_P08842
    UniProt: P08842

  • Chr Location
    Xp22.31; chrX:7147237-7804358 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    48
  • Tissues
    39
  • cDNA Data
    9
  • Literature Summary
    3
  • Other Mouse Links
    GEO
  • Other Vertebrate Links
    Xenbase sts
Sequences &
Gene Models
less
  • All Sequences
    10
  • RefSeq
    2
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000121914 Ensembl Gene Model | MGI Sequence Detail 105895 C57BL/6J ±  kb
transcript ENSMUST00000249673 Ensembl | MGI Sequence Detail 1125 Not Applicable  
polypeptide ENSMUSP00000159851 Ensembl | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.6.2
  • InterPro Domains
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR024607 Sulfatase, conserved site
    IPR050738 Sulfatase enzyme
    IPR000917 Sulfatase, N-terminal
  • GlyGen
    P50427 2 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 11
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14637
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 1
  • Earliest
    J:7044 Gartler SM, et al., Evidence for X-linkage of steroid sulfatase in the mouse: steroid sulfatase levels in oocytes of XX and XO mice. Genetics. 1983 Jan;103(1):137-41
  • Latest
    J:280389 Feng Y, et al., Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice. J Biol Chem. 2019 Aug 9;294(32):12112-12121
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory