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Syp Gene Detail
Summary
  • Symbol
    Syp
  • Name
    synaptophysin
  • Synonyms
    A230093K24Rik, p38, Syn, Syp I
  • Feature Type
    protein coding gene
  • IDs
    MGI:98467
    NCBI Gene: 20977
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7504819-7519495 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.44 cM, cytoband A-D
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98467
 protein coding gene ChrX:7504710-7519495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035515
 protein coding gene ChrX:2251412-2266725 (+)
A/J MGP_AJ_G0035493
 protein coding gene ChrX:2211985-2228064 (+)
AKR/J MGP_AKRJ_G0035426
 protein coding gene ChrX:2313321-2329987 (+)
BALB/cJ MGP_BALBcJ_G0035489
 protein coding gene ChrX:2230983-2246302 (+)
C3H/HeJ MGP_C3HHeJ_G0035197
 protein coding gene ChrX:2285371-2300049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036013
 protein coding gene ChrX:2328614-2343300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032888
 protein coding gene ChrX:1780007-1794574 (+)
CAST/EiJ MGP_CASTEiJ_G0034497
 protein coding gene ChrX:2185319-2200904 (+)
CBA/J MGP_CBAJ_G0035167
 protein coding gene ChrX:2441707-2460736 (+)
DBA/2J MGP_DBA2J_G0035324
 protein coding gene ChrX:2232988-2247681 (+)
FVB/NJ MGP_FVBNJ_G0035271
 protein coding gene ChrX:2196928-2211515 (+)
LP/J MGP_LPJ_G0035401
 protein coding gene ChrX:2252795-2267495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035310
 protein coding gene ChrX:2406165-2423238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036031
 protein coding gene ChrX:2234384-2249063 (+)
PWK/PhJ MGP_PWKPhJ_G0034199
 protein coding gene ChrX:2165518-2180740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034036
 protein coding gene ChrX:2204691-2219255 (+)
WSB/EiJ MGP_WSBEiJ_G0034620
 protein coding gene ChrX:2237069-2254581 (+)



Homology
more
  • Human Ortholog
    SYP, synaptophysin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYP, synaptophysin
  • Synonyms
    MRX96, MRXSYP, XLID96
  • Links
    NCBI Gene ID: 6855
    neXtProt AC: NX_P08247
    UniProt: P08247

  • Chr Location
    Xp11.23; chrX:49187815-49200218 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SYP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1086
  • Tissues
    149
  • cDNA Data
    110
  • Literature Summary
    312
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20977 NCBI Gene Model | MGI Sequence Detail 14677 C57BL/6J ±  kb
transcript NM_009305 RefSeq | MGI Sequence Detail 2482 ZRU/MplStud  
polypeptide Q62277 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 128
    Genomic 12
    cDNA 113
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14690, MGI:2147923, MGI:2441790
References
more
  • Summaries
    All 422
    Developmental Gene Expression 312
    Gene Ontology 44
    Phenotypes 26
  • Earliest
    J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
  • Latest
    J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory