Tacr2 MGI Mouse Gene Detail - MGI:98477

Symbol

Tacr2
Name

tachykinin receptor 2
Synonyms

Tac2r

Feature Type

protein coding gene
IDs

MGI:98477
NCBI Gene: 21337
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:62088217-62101769 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.37 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

652 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98477	protein coding gene	Chr10:62088217-62101769 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017294	protein coding gene	Chr10:61663560-61680443 (+)
A/J	MGP_AJ_G0017272	protein coding gene	Chr10:59789044-59802492 (+)
AKR/J	MGP_AKRJ_G0017232	protein coding gene	Chr10:61348686-61362048 (+)
BALB/cJ	MGP_BALBcJ_G0017232	protein coding gene	Chr10:59867961-59881411 (+)
C3H/HeJ	MGP_C3HHeJ_G0017055	protein coding gene	Chr10:61264947-61279534 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017690	protein coding gene	Chr10:63888757-63903455 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015380	protein coding gene	Chr10:56759525-56773762 (+)
CAST/EiJ	MGP_CASTEiJ_G0016626	protein coding gene	Chr10:61301517-61318017 (+)
CBA/J	MGP_CBAJ_G0017027	protein coding gene	Chr10:66272817-66288757 (+)
DBA/2J	MGP_DBA2J_G0017132	protein coding gene	Chr10:59060673-59074067 (+)
FVB/NJ	MGP_FVBNJ_G0017126	protein coding gene	Chr10:58322955-58336715 (+)
LP/J	MGP_LPJ_G0017206	protein coding gene	Chr10:62056118-62071121 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017154	protein coding gene	Chr10:68506293-68530991 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017728	protein coding gene	Chr10:61183095-61196656 (+)
PWK/PhJ	MGP_PWKPhJ_G0016409	protein coding gene	Chr10:58919136-58934004 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016191	protein coding gene	Chr10:60561749-60575709 (+)
WSB/EiJ	MGP_WSBEiJ_G0016690	protein coding gene	Chr10:61111992-61128564 (+)

Human Ortholog

TACR2, tachykinin receptor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TACR2, tachykinin receptor 2
Synonyms

NK2R, NKNAR, SKR, TAC2R
Links

HGNC:11527

NCBI Gene ID: 6865

neXtProt AC: NX_P21452

UniProt: P21452
Chr Location

10q22.1; chr10:69403903-69416918 (-) GRCh38

MGI Vertebrate Homology

Tacr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TACR2
Gene Tree

Tacr2

Diseases

1 with human TACR2 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tacr2
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display abnormalities in luteinizing hormone levels in females and increased glucose levels in males on a high fat diet.

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All GO Annotations

35
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

23
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS35919.1

Ensembl

ENSMUSG00000020081 (Evidence)
NCBI Gene

21337

			Length	Strain/Species	Flank
genomic	21337	NCBI Gene Model \| MGI Sequence Detail	13553	C57BL/6J	± kb
transcript	NM_009314	RefSeq \| MGI Sequence Detail	2258	C57BL/6
polypeptide	P30549	UniProt \| EBI \| MGI Sequence Detail	384	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001246 substance-K receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000913 Neurokinin NK2 receptor

IPR001681 Neurokinin receptor
GlyGen

P30549 1 site

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All nucleic 15

Genomic 3

cDNA 9

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-14704

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:337866 Shen W, et al., IFN-gamma-STAT1-mediated NK2R expression is involved in the induction of antitumor effector CD8(+) T cells in vivo. Cancer Sci. 2023 May;114(5):1816-1829

TSS for Tacr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93699	Chr10:62088104-62088136 (+)	-97 bp
Tssr93700	Chr10:62088510-62088545 (+)	311 bp
Tssr93701	Chr10:62088826-62088836 (+)	614 bp
Tssr93702	Chr10:62088869-62088887 (+)	661 bp
Tssr93703	Chr10:62088890-62088900 (+)	678 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24