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Tal1 Gene Detail
Summary
  • Symbol
    Tal1
  • Name
    T cell acute lymphocytic leukemia 1
  • Synonyms
    bHLHa17, Hpt, Scl, SCL/tal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98480
    NCBI Gene: 21349
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:114913623-114928952 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 52.73 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98480
 protein coding gene Chr4:114913623-114928952 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028594
 protein coding gene Chr4:115825398-115840634 (+)
A/J MGP_AJ_G0028556
 protein coding gene Chr4:111415791-111432255 (+)
AKR/J MGP_AKRJ_G0028504
 protein coding gene Chr4:113711179-113727417 (+)
BALB/cJ MGP_BALBcJ_G0028576
 protein coding gene Chr4:112043031-112058829 (+)
C3H/HeJ MGP_C3HHeJ_G0028290
 protein coding gene Chr4:115330237-115345622 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029020
 protein coding gene Chr4:120302245-120320534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026304
 protein coding gene Chr4:105500959-105515901 (+)
CAST/EiJ MGP_CASTEiJ_G0027727
 protein coding gene Chr4:112748334-112763575 (+)
CBA/J MGP_CBAJ_G0028258
 protein coding gene Chr4:123422631-123440212 (+)
DBA/2J MGP_DBA2J_G0028407
 protein coding gene Chr4:112047262-112062577 (+)
FVB/NJ MGP_FVBNJ_G0028375
 protein coding gene Chr4:110519714-110534962 (+)
LP/J MGP_LPJ_G0028508
 protein coding gene Chr4:116028232-116048182 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028400
 protein coding gene Chr4:128563802-128579122 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029056
 protein coding gene Chr4:114959631-114974942 (+)
PWK/PhJ MGP_PWKPhJ_G0027452
 protein coding gene Chr4:108844162-108859844 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027276
 protein coding gene Chr4:111354942-111370168 (+)
WSB/EiJ MGP_WSBEiJ_G0027805
 protein coding gene Chr4:114740729-114756068 (+)



Homology
more
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAL1, TAL bHLH transcription factor 1, erythroid differentiation factor
  • Synonyms
    bHLHa17, SCL, tal-1, TCL5
  • Links
    NCBI Gene ID: 6886
    neXtProt AC: NX_P17542
    UniProt: P17542

  • Chr Location
    1p33; chr1:47216290-47232335 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tal1 mouse models; 1 with human TAL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 10 alleles in 10 genetic backgrounds
    2 images
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1253
  • Tissues
    310
  • cDNA Data
    35
  • Literature Summary
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21349 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
    transcript NM_001425784 RefSeq | MGI Sequence Detail 4649 C57BL/6  
    polypeptide P22091 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016043 T-cell acute lymphocytic leukemia protein 1
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR040238 Helix-loop-helix protein TAL-like
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 3
      cDNA 35
      Primer pair 17
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10924, MGD-MRK-14313, MGD-MRK-14708, MGI:96219
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 100
      Diseases 1
      Gene Ontology 47
      Phenotypes 74
    • Earliest
      J:8017 Blackwell JM, et al., Response of BALB/c mice to leishmanial infection. Curr Top Microbiol Immunol. 1985;122:97-106
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory