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Tat Gene Detail
Summary
  • Symbol
    Tat
  • Name
    tyrosine aminotransferase
  • Synonyms
    MGC:37772, MGC:37789, MGC:37790, MGC:37819, MGC:37828, MGC:37842
  • Feature Type
    protein coding gene
  • IDs
    MGI:98487
    NCBI Gene: 234724
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110717069-110726435 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.38 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98487
 protein coding gene Chr8:110712710-110726436 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034117
 protein coding gene Chr8:112613372-112622738 (+)
A/J MGP_AJ_G0034096
 protein coding gene Chr8:108049305-108058671 (+)
AKR/J MGP_AKRJ_G0034023
 protein coding gene Chr8:111218758-111228124 (+)
BALB/cJ MGP_BALBcJ_G0034090
 protein coding gene Chr8:108256601-108265967 (+)
C3H/HeJ MGP_C3HHeJ_G0033801
 protein coding gene Chr8:111923669-111933035 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034610
 protein coding gene Chr8:116597303-116606669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031552
 protein coding gene Chr8:101080511-101090104 (+)
CAST/EiJ MGP_CASTEiJ_G0033128
 protein coding gene Chr8:111530218-111539641 (+)
CBA/J MGP_CBAJ_G0033775
 protein coding gene Chr8:120503392-120512758 (+)
DBA/2J MGP_DBA2J_G0033930
 protein coding gene Chr8:107375913-107385279 (+)
FVB/NJ MGP_FVBNJ_G0033874
 protein coding gene Chr8:106321059-106330425 (+)
LP/J MGP_LPJ_G0034020
 protein coding gene Chr8:112792831-112802197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033920
 protein coding gene Chr8:123515199-123525022 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034629
 protein coding gene Chr8:111178098-111187464 (+)
PWK/PhJ MGP_PWKPhJ_G0032831
 protein coding gene Chr8:106937536-106976872 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032670
 protein coding gene Chr8:109860202-109870815 (+)
WSB/EiJ MGP_WSBEiJ_G0033244
 protein coding gene Chr8:111866259-111875621 (+)



Homology
more
  • Human Ortholog
    TAT, tyrosine aminotransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAT, tyrosine aminotransferase
  • Links
    NCBI Gene ID: 6898
    neXtProt AC: NX_P17735
    UniProt: P17735

  • Chr Location
    16q22.2; chr16:71565660-71577092 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TAT associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    103
  • cDNA Data
    118
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001670 Ensembl Gene Model | MGI Sequence Detail 9367 C57BL/6J ±  kb
    transcript ENSMUST00000001720 Ensembl | MGI Sequence Detail 2375 Not Applicable  
    polypeptide ENSMUSP00000001720 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016089 tyrosine aminotransferase
      (term hierarchy)
    • PDB
      3PDX
    • EC
      2.6.1.5
    • InterPro Domains
      IPR004839 Aminotransferase, class I/classII
      IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
      IPR005957 Tyrosine aminotransferase
      IPR011715 Tyrosine aminotransferase ubiquitination region
      IPR005958 Tyrosine/nicotianamine aminotransferase
    Molecular
    Reagents
    less
    • All nucleic 137
      Genomic 9
      cDNA 120
      Primer pair 6
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14719
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 19
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:25840 Blake RL, Regulation of liver tyrosine aminotransferase activity in inbred strains and mutant mice, I. Strain variance in fasting enzyme levels. Int J Biochem. 1970;1:361-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory