Tbxa2r MGI Mouse Gene Detail - MGI:98496

Symbol

Tbxa2r
Name

thromboxane A2 receptor
Synonyms

TP, Tp receptor

Feature Type

protein coding gene
IDs

MGI:98496
NCBI Gene: 21390
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:81164565-81171006 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

4 experiments

SNPs within 2kb

211 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98496	protein coding gene	Chr10:81164102-81171008 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017551	protein coding gene	Chr10:82041124-82047777 (+)
A/J	MGP_AJ_G0017529	protein coding gene	Chr10:79132357-79138737 (+)
AKR/J	MGP_AKRJ_G0017490	protein coding gene	Chr10:81305872-81313823 (+)
BALB/cJ	MGP_BALBcJ_G0017491	protein coding gene	Chr10:79351972-79358874 (+)
C3H/HeJ	MGP_C3HHeJ_G0017314	protein coding gene	Chr10:81405799-81413222 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017945	protein coding gene	Chr10:84857173-84864766 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015634	protein coding gene	Chr10:75329336-75335640 (+)
CAST/EiJ	MGP_CASTEiJ_G0016881	protein coding gene	Chr10:81635083-81641541 (+)
CBA/J	MGP_CBAJ_G0017286	protein coding gene	Chr10:88164808-88174659 (+)
DBA/2J	MGP_DBA2J_G0017392	protein coding gene	Chr10:78337266-78343684 (+)
FVB/NJ	MGP_FVBNJ_G0017386	protein coding gene	Chr10:77585726-77593102 (+)
LP/J	MGP_LPJ_G0017463	protein coding gene	Chr10:82488337-82494649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017412	protein coding gene	Chr10:90011269-90018578 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017986	protein coding gene	Chr10:81315489-81322681 (+)
PWK/PhJ	MGP_PWKPhJ_G0016662	protein coding gene	Chr10:78230381-78237586 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016452	protein coding gene	Chr10:80257642-80266143 (+)
WSB/EiJ	MGP_WSBEiJ_G0016941	protein coding gene	Chr10:81342824-81351435 (+)

Human Ortholog

TBXA2R, thromboxane A2 receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBXA2R, thromboxane A2 receptor
Synonyms

BDPLT13, TXA2-R
Links

HGNC:11608

NCBI Gene ID: 6915

neXtProt AC: NX_P21731

UniProt: P21731
Chr Location

19p13.3; chr19:3594507-3606875 (-) GRCh38

MGI Vertebrate Homology

Tbxa2r stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBXA2R
Gene Tree

Tbxa2r

Diseases

3 with human TBXA2R associations

				Human Disease	Mouse Models
				aspirin-induced respiratory disease IDs aspirin-induced respiratory disease DOID:0080822
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				blood platelet disease IDs blood platelet disease DOID:2218 MESH:D001791 NCI:C131634 UMLS_CUI:C0005818

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 3 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Tbxa2r
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy.

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All GO Annotations

38
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

45
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbxa2r

ZFIN tbxa2r

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS24053.1

Ensembl

ENSMUSG00000034881 (Evidence)
NCBI Gene

21390

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034881	Ensembl Gene Model \| MGI Sequence Detail	6442	C57BL/6J	± kb
transcript	ENSMUST00000220312	Ensembl \| MGI Sequence Detail	1919	Not Applicable
polypeptide	ENSMUSP00000151447	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001676 thromboxane A2 receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR008365 Prostanoid receptor

IPR001105 Thromboxane receptor
GlyGen

P30987 2 sites

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

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MGD-MRK-14733

Summaries

All 101

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 55
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11

TSS for Tbxa2r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94739	Chr10:81164520-81164538 (+)	-36 bp
Tssr94740	Chr10:81164553-81164573 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24