Tcm Gene Detail

Summary

• Symbol
  Tcm
• Name
  total cataract with microphthalmia

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:98533
  NCBI Gene: 110289
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic
• Mapping Data
  2 experiments

Human Diseases

• Diseases
  1 with Tcm mouse models

Human Disease

Mouse Models

cataract

IDs

cataract      

DOID:83
ICD10CM:H26
ICD9CM:366.8
OMIM:601371
OMIM:PS116200
UMLS_CUI:C0029531

View 1 model

Mouse Models

Human Disease Modeled: cataract

Allelic Composition	Genetic Background	Reference	Phenotypes
Tcm/Tcm+	involves: 101 * C3H	J:9528	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 2 genetic backgrounds
  2 images
  4 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  0 strains or lines available

Both homozygotes and heterozygotes exhibit total opacity and dysplasia of the lens, reduced pupils, iris dysplasia, and microphthalmia.

Sequences &
Gene Models

• NCBI Gene
  110289

Other
Accession IDs

MGD-MRK-14806

References

• Summaries
  All 5

  Diseases 1

  Phenotypes 4
• Earliest
  J:52633 Graw J, et al., Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice. Mutat Res. 1986 Jan-Feb;159(1-2):47-54
• Latest
  J:100636 Wang KS, et al., Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Mamm Genome. 2005 May;16(5):332-43