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Tcp1 Gene Detail
Summary
  • Symbol
    Tcp1
  • Name
    t-complex protein 1
  • Synonyms
    c-cpn, CCT, Cct1, Ccta, p63, Tcp-1, Tp63, TRic
  • Feature Type
    protein coding gene
  • IDs
    MGI:98535
    NCBI Gene: 21454
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:13135216-13143954 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.72 cM, cytoband A3-B
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98535
 protein coding gene Chr17:13134588-13143954 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023154
 protein coding gene Chr17:10586739-10618978 (+)
A/J MGP_AJ_G0023122
 protein coding gene Chr17:10417379-10426134 (+)
AKR/J MGP_AKRJ_G0023086
 protein coding gene Chr17:10246832-10261087 (+)
BALB/cJ MGP_BALBcJ_G0023122
 protein coding gene Chr17:10196276-10208865 (+)
C3H/HeJ MGP_C3HHeJ_G0022885
 protein coding gene Chr17:10497116-10506131 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023565
 protein coding gene Chr17:10987344-11001617 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021043
 protein coding gene Chr17:4024762-4034797 (-)
CAST/EiJ MGP_CASTEiJ_G0022399
 protein coding gene Chr17:10581250-10591104 (+)
CBA/J MGP_CBAJ_G0022857
 protein coding gene Chr17:11406419-11415225 (+)
DBA/2J MGP_DBA2J_G0022990
 protein coding gene Chr17:10053950-10062801 (+)
FVB/NJ MGP_FVBNJ_G0022960
 protein coding gene Chr17:9990600-9999841 (+)
LP/J MGP_LPJ_G0023062
 protein coding gene Chr17:10432205-10441515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022979
 protein coding gene Chr17:11006428-11015239 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023591
 protein coding gene Chr17:10522023-10531677 (+)
PWK/PhJ MGP_PWKPhJ_G0022147
 protein coding gene Chr17:9745835-9754851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021977
 protein coding gene Chr17:9952529-9961900 (+)
WSB/EiJ MGP_WSBEiJ_G0022456
 protein coding gene Chr17:10834489-10844383 (+)



Homology
more
  • Human Ortholog
    TCP1, t-complex 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCP1, t-complex 1
  • Synonyms
    CCT1, CCTa, CCT-alpha, D6S230E, TCP-1-alpha
  • Links
    NCBI Gene ID: 6950
    neXtProt AC: NX_P17987
    UniProt: P17987

  • Chr Location
    6q25.3; chr6:159778498-159789703 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
There are two electrophoretic alleles known; allele a occurs in all complete t haplotype chromosomes and allele b in wild-type strains. There are multiple changes between the amino acid sequences of the TCP1A and TCP1B proteins encoded by the two alleles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    25
  • cDNA Data
    39
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21454 NCBI Gene Model | MGI Sequence Detail 8739 C57BL/6J ±  kb
transcript NM_013686 RefSeq | MGI Sequence Detail 2499 ZRU/MplStud  
polypeptide P11983 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005149 T-complex protein 1 subunit alpha
    (term hierarchy)
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain superfamily
    IPR027413 GroEL-like equatorial domain superfamily
    IPR012715 T-complex protein 1, alpha subunit
    IPR053374 TCP-1 chaperonin-containing T-complex
    IPR027410 TCP-1-like chaperonin intermediate domain superfamily
  • GlyGen
    P11983 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 67
    Genomic 20
    cDNA 41
    Primer pair 2
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13116, MGD-MRK-14810, MGD-MRK-14826, MGD-MRK-15176, MGD-MRK-36524, MGI:107944, MGI:2146890
References
more
  • Summaries
    All 109
    Developmental Gene Expression 10
    Gene Ontology 14
    Phenotypes 10
  • Earliest
    J:6159 Silver LM, et al., A major testicular cell protein specified by a mouse T/t complex gene. Cell. 1979 Jun;17(2):275-84
  • Latest
    J:345345 Chen J, et al., Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle alpha-actin from the chaperonin-containing TCP1 folding complex. J Biol Chem. 2021 Dec;297(6):101228
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory