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Tcrb Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcrb
  • Name
    T cell receptor beta chain
  • Synonyms
    TCRbeta, Tib
Location &
Maps
more
  • Sequence Map
    Chr6:40868230-41535305 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, cytoband A-C
  • Mapping Data
    68 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18095 from dbSNP Build 142
  • PCR
    3
  • RFLP
    13
Human Diseases
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  • Mutations/Alleles
    13 with disease annotations
  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 20 alleles in 13 genetic backgrounds
    275 phenotypes from multigenic genotypes
    2 images
    6220 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display thymic hypoplasia, impaired Tcrb V(D)J recombinations, and arrested alphabeta T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    15
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    Sequences &
    Gene Models
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    • All Sequences
      4
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21577 NCBI Gene Model | MGI Sequence Detail 667076 C57BL/6J ±  kb
    transcript X00439 GenBank | ENA | DDBJ | MGI Sequence Detail 389 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 6
      Primer pair 6
      Other 2
    Other
    Accession IDs
    less
    MGD-MRK-14870, MGD-MRK-15107
    References
    more
    • Summaries
      All 6456
      Developmental Gene Expression 9
      Diseases 16
      Gene Ontology 17
      Phenotypes 6220
    • Earliest
      J:7353 Hedrick SM, et al., Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14;308(5955):149-53
    • Latest
      J:359183 Singh S, et al., Rab8a restores diverse innate functions in CD11c(+)CD11b(+) dendritic cells from aged mice. Nat Commun. 2024 Nov 27;15(1):10300
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory