Trbv15 Gene Detail

Summary

• Symbol
  Trbv15
• Name
  T cell receptor beta, variable 15
• Synonyms
  Gm16775

• Feature Type
  gene segment
• IDs
  MGI:98586
  NCBI Gene: 100124679
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr6:41118145-41118592 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 19.23 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  89 from dbSNP Build 142
• Strain Annotations
  17
• RFLP
  3

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98586	gene segment	Chr6:41118122-41118592 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0002587	gene segment	Chr6:39625957-39626427 (+)
A/J	MGP_AJ_G0002558	gene segment	Chr6:37895754-37896224 (+)
AKR/J	MGP_AKRJ_G0002549	gene segment	Chr6:39100345-39100815 (+)
BALB/cJ	MGP_BALBcJ_G0002544	gene segment	Chr6:38108538-38109008 (+)
C3H/HeJ	MGP_C3HHeJ_G0002511	gene segment	Chr6:39127680-39128150 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0002685	gene segment	Chr6:40605829-40606299 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002254	gene segment	Chr6:35685826-35686296 (+)
CAST/EiJ	MGP_CASTEiJ_G0002496	gene segment	Chr6:39013567-39014037 (+)
CBA/J	MGP_CBAJ_G0002510	gene segment	Chr6:42252448-42252918 (+)
DBA/2J	MGP_DBA2J_G0002514	gene segment	Chr6:37710373-37710843 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0002593	gene segment	Chr6:39632559-39633029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002517	gene segment	Chr6:44491403-44491873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002695	gene segment	Chr6:39078306-39078776 (+)
PWK/PhJ	MGP_PWKPhJ_G0002456	gene segment	Chr6:37333759-37334229 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0002408	gene segment	Chr6:38770666-38771136 (+)
WSB/EiJ	MGP_WSBEiJ_G0002512	gene segment	Chr6:39007648-39008118 (+)

Homology

• Human Ortholog
  TRBV12-3, T cell receptor beta variable 12-3

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRBV12-3, T cell receptor beta variable 12-3
  
• Synonyms
  TCRBV12S3, TCRBV8S1, TRBV123
• Links
  HGNC:12185

  NCBI Gene ID: 28577

  UniProt: P01733

  
  
• Chr Location
  7q34; chr7:142560423-142560931 (+)  GRCh38

---

• Human Ortholog
  TRBV12-4, T cell receptor beta variable 12-4
  
• Synonyms
  TCRBV12S4, TCRBV8S2A1T, TRBV124
• Links
  HGNC:12186

  NCBI Gene ID: 28576

  UniProt: A0A0B4J2E0

  
  
• Chr Location
  7q34; chr7:142563740-142564245 (+)  GRCh38

---

• MGI Vertebrate Homology
  Trbv15 stringent orthology
  2 human;1 mouse
  
• HCOP
  vertebrate homology predictions: TRBV12-3, TRBV12-4
• Gene Tree
  Trbv15
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  10 strains or lines available

Mice homozygous for a knock-in allele exhibit altered rearrangement and allelic exclusion of the nearest Vbeta segment in the double-negative compartment; however, feedback inhibition of Vbeta-to-DJbeta recombination remains intact in the double-positivecompartment.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  1

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  23
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000076472 (Evidence)
• NCBI Gene
  100124679

Representative Sequences			Length	Strain/Species
genomic	100124679	NCBI Gene Model | MGI Sequence Detail	448	C57BL/6J
polypeptide	A0A0A6YYE3	UniProt | EBI | MGI Sequence Detail	115	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR013106 Immunoglobulin V-set domain
  IPR050413 T cell receptor beta variable

Molecular
Reagents

• All nucleic 5

  Genomic 4

  cDNA 1

Other
Accession IDs

MGD-MRK-14878, MGI:4439699

References

• Summaries
  All 13

  Gene Ontology 1

  Phenotypes 2
• Earliest
  J:8182 Behlke MA, et al., Murine T-cell receptor mutants with deletions of beta-chain variable region genes. Proc Natl Acad Sci U S A. 1986 Feb;83(3):767-71
• Latest
  J:220526 Del Blanco B, et al., T-cell receptor alpha enhancer is inactivated in alphabeta T lymphocytes. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1744-53

TSS for Trbv15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55831	Chr6:41118078-41118116 (+)	-48 bp
Tssr55832	Chr6:41118120-41118133 (+)	-18 bp
Tssr55833	Chr6:41118216-41118227 (+)	77 bp
Tssr55834	Chr6:41118231-41118241 (+)	91 bp