Trbv12-1 Gene Detail

Summary

• Symbol
  Trbv12-1
• Name
  T cell receptor beta, variable 12-1
• Synonyms
  Gm16753

• Feature Type
  gene segment
• IDs
  MGI:98602
  NCBI Gene: 100124672
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr6:41090501-41091001 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 19.19 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  142 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98602	gene segment	Chr6:41090484-41091001 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0002581	gene segment	Chr6:39593705-39594222 (+)
A/J	MGP_AJ_G0002552	gene segment	Chr6:37867985-37868502 (+)
AKR/J	MGP_AKRJ_G0002543	gene segment	Chr6:39070618-39071135 (+)
BALB/cJ	MGP_BALBcJ_G0002538	gene segment	Chr6:38079990-38080507 (+)
C3H/HeJ	MGP_C3HHeJ_G0002505	gene segment	Chr6:39093926-39094443 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0002679	gene segment	Chr6:40579175-40579692 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002248	gene segment	Chr6:35658042-35658658 (+)
CAST/EiJ	MGP_CASTEiJ_G0002490	gene segment	Chr6:38984155-38984690 (+)
CBA/J	MGP_CBAJ_G0002504	gene segment	Chr6:42214293-42214810 (+)
DBA/2J	MGP_DBA2J_G0002508	gene segment	Chr6:37681113-37681630 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0002587	gene segment	Chr6:39605983-39606500 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002511	gene segment	Chr6:44464807-44465324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002689	gene segment	Chr6:39046653-39047170 (+)
PWK/PhJ	MGP_PWKPhJ_G0002450	gene segment	Chr6:37306139-37306707 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0002402	gene segment	Chr6:38740160-38740659 (+)
WSB/EiJ	MGP_WSBEiJ_G0002506	gene segment	Chr6:38977026-38977528 (+)

Homology

• Human Ortholog
  TRBV13, T cell receptor beta variable 13

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRBV13, T cell receptor beta variable 13
  
• Synonyms
  TCRBV13S1, TCRBV23S1A2T
• Links
  HGNC:12188

  NCBI Gene ID: 28574

  UniProt: A0A0A6YYD4

  
  
• Chr Location
  7q34; chr7:142535809-142536292 (+)  GRCh38

---

• Human Ortholog
  TRBV5-1, T cell receptor beta variable 5-1
  
• Synonyms
  TCRBV5S1, TCRBV5S1A1T, TRBV51
• Links
  HGNC:12218

  NCBI Gene ID: 28614

  UniProt: A0A578

  
  
• Chr Location
  7q34; chr7:142320677-142321544 (+)  GRCh38

---

• Human Ortholog
  TRBV5-3, T cell receptor beta variable 5-3 (non-functional)
  
• Synonyms
  TCRBV5S3, TCRBV5S5P, TRBV53
• Links
  HGNC:12220

  NCBI Gene ID: 28612

  UniProt: A0A0A0MS03

  
  
• Chr Location
  7q34; chr7:142389202-142389668 (+)  GRCh38

---

• Human Ortholog
  TRBV5-8, T cell receptor beta variable 5-8
  
• Synonyms
  TCRBV5S4A2T, TCRBV5S8, TRBV58
• Links
  HGNC:12225

  NCBI Gene ID: 28607

  UniProt: A0A5A2

  
  
• Chr Location
  7q34

---

• MGI Vertebrate Homology
  Trbv12-1 stringent orthology
  4 human;1 mouse
  
• HCOP
  vertebrate homology predictions: TRBV13, TRBV5-1, TRBV5-3, TRBV5-8
• Gene Tree
  Trbv12-1
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  4 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  24
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000095574 (Evidence)
• NCBI Gene
  100124672

Representative Sequences			Length	Strain/Species
genomic	100124672	NCBI Gene Model | MGI Sequence Detail	501	C57BL/6J
polypeptide	A0A0B4J1H0	UniProt | EBI | MGI Sequence Detail	124	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR013106 Immunoglobulin V-set domain
  IPR050413 T cell receptor beta variable

Molecular
Reagents

• All nucleic 10

  Genomic 9

  Other 1

Other
Accession IDs

MGD-MRK-14894, MGI:4439677

References

• Summaries
  All 10

  Gene Ontology 1
• Earliest
  J:8736 Lai E, et al., Genomic organization of the mouse T-cell receptor beta-chain gene family. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3846-50
• Latest
  J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Trbv12-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55808	Chr6:41090302-41090313 (+)	-193 bp
Tssr55809	Chr6:41090450-41090481 (+)	-35 bp
Tssr55810	Chr6:41090486-41090515 (+)	0 bp
Tssr55811	Chr6:41090516-41090527 (+)	21 bp