Trbv19 MGI Mouse Gene Detail - MGI:98604 - T cell receptor beta, variable 19

Symbol

Trbv19
Name

T cell receptor beta, variable 19
Synonyms

Gm16780

Feature Type

gene segment
IDs

MGI:98604
NCBI Gene: 100124684
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:41155523-41155982 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 19.27 cM
Mapping Data

2 experiments

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98604	gene segment	Chr6:41155309-41155982 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0002590	gene segment	Chr6:39665798-39666471 (+)
A/J	MGP_AJ_G0002561	gene segment	Chr6:37933113-37933786 (+)
AKR/J	MGP_AKRJ_G0002552	gene segment	Chr6:39142270-39142943 (+)
BALB/cJ	MGP_BALBcJ_G0002547	gene segment	Chr6:38153771-38154444 (+)
C3H/HeJ	MGP_C3HHeJ_G0002514	gene segment	Chr6:39168077-39168750 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0002688	gene segment	Chr6:40642221-40642894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002257	gene segment	Chr6:35726993-35727679 (+)
CAST/EiJ	MGP_CASTEiJ_G0002499	gene segment	Chr6:39061022-39061693 (+)
CBA/J	MGP_CBAJ_G0002513	gene segment	Chr6:42301822-42302495 (+)
DBA/2J	MGP_DBA2J_G0002517	gene segment	Chr6:37748343-37749016 (+)
FVB/NJ	MGP_FVBNJ_G0002536	gene segment	Chr6:37502852-37503525 (+)
LP/J	MGP_LPJ_G0002596	gene segment	Chr6:39669886-39670559 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002520	gene segment	Chr6:44543138-44543811 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002698	gene segment	Chr6:39115247-39115920 (+)
PWK/PhJ	MGP_PWKPhJ_G0002459	gene segment	Chr6:37373914-37374587 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0002411	gene segment	Chr6:38813959-38814642 (+)
WSB/EiJ	MGP_WSBEiJ_G0002515	gene segment	Chr6:39045420-39046091 (+)

Human Ortholog

TRBV19, T cell receptor beta variable 19

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRBV19, T cell receptor beta variable 19
Synonyms

TCRBV17S1A1T, TCRBV19S1
Links

HGNC:12194

NCBI Gene ID: 28568

UniProt: A0A075B6N1
Chr Location

7q34; chr7:142618849-142619532 (+) GRCh38

MGI Vertebrate Homology

Trbv19 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: TRBV19
Gene Tree

Trbv19

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Expression Atlas

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All Sequences

24
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000076475 (Evidence)
NCBI Gene

100124684

Representative Sequences				Length	Strain/Species	Flank
	genomic	100124684	NCBI Gene Model \| MGI Sequence Detail	460	C57BL/6J	± kb
	polypeptide	A0A0B4J1H4	UniProt \| EBI \| MGI Sequence Detail	117	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain

IPR050413 T cell receptor beta variable

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All nucleic 21

Genomic 6

cDNA 14

Other 1

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MGD-MRK-14896, MGI:4439704

Summaries

All 19

Gene Ontology 2

Phenotypes 3
Earliest

J:7628 Patten P, et al., Structure, expression and divergence of T-cell receptor beta-chain variable regions. Nature. 1984 Nov 1-7;312(5989):40-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trbv19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55844	Chr6:41154375-41154402 (+)	-1,134 bp
Tssr55845	Chr6:41154438-41154450 (+)	-1,079 bp
Tssr55846	Chr6:41155096-41155100 (+)	-425 bp
Tssr55847	Chr6:41155242-41155251 (+)	-276 bp
Tssr55848	Chr6:41155254-41155269 (+)	-261 bp
Tssr55849	Chr6:41155314-41155335 (+)	-198 bp
Tssr55850	Chr6:41155342-41155387 (+)	-158 bp
Tssr55851	Chr6:41155417-41155440 (+)	-94 bp
Tssr55852	Chr6:41155665-41155682 (+)	151 bp
Tssr55853	Chr6:41155772-41155794 (+)	260 bp
Tssr55854	Chr6:41155916-41155930 (+)	400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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