Tcrg MGI Mouse Complex/Cluster/Region Detail - MGI:98623

Tcrg Complex/Cluster/Region Detail

Sequence Map

Chr13:19362212-19540646 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

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Phenotype Summary

14 phenotypes from 7 alleles in 5 genetic backgrounds
6 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

Mice that are homozygous for a null mutation lack gammadelta T cells.

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Comparison Matrix

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Representative Sequences				Length	Strain/Species	Flank
	genomic	110067	NCBI Gene Model \| MGI Sequence Detail	178435	C57BL/6J	± kb
	transcript	X04699	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	1423	Not Specified

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MGD-MRK-14915

Summaries

All 173

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 30
Earliest

J:7491 Saito H, et al., Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature. 1984 Jun 28-Jul 4;309(5971):757-62
Latest

J:326403 Rampoldi F, et al., gammadelta T cells license immature B cells to produce a broad range of polyreactive antibodies. Cell Rep. 2022 May 24;39(8):110854

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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