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Dynlt2a1 Gene Detail
Summary
  • Symbol
    Dynlt2a1
  • Name
    dynein light chain Tctex-type 2A1
  • Synonyms
    D17Leh117c, Dynlt2, LC2, Tcte-3, Tcte3, Tctex-2, Tctex2, Tctex-4, Tctex4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98642
    NCBI Gene: 21647
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:15247414-15261750 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98642
 protein coding gene Chr17:15233025-15261821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023170
 protein coding gene Chr17:12846163-12861948 (-)
A/J MGP_AJ_G0023136
 protein coding gene Chr17:12611541-12629407 (-)
AKR/J MGP_AKRJ_G0023106
 protein coding gene Chr17:12521353-12536417 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023579
 protein coding gene Chr17:13375317-13390601 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021091
 protein coding gene Chr17:10631839-10646153 (-)
CAST/EiJ MGP_CASTEiJ_G0022414
 protein coding gene Chr17:12642468-12657307 (-)
CBA/J MGP_CBAJ_G0022873
 protein coding gene Chr17:13792687-13819339 (-)
DBA/2J MGP_DBA2J_G0023004
 protein coding gene Chr17:12301939-12345403 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0023080
 protein coding gene Chr17:12766765-12781674 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022995
 protein coding gene Chr17:13440405-13457926 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023615
 protein coding gene Chr17:12805178-12821120 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021992
 protein coding gene Chr17:11728780-11763884 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DYNLT2, dynein light chain Tctex-type 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNLT2, dynein light chain Tctex-type 2
  • Synonyms
    oda12, TCTE3, TCTEX1D3, TCTEX2, Tctex4
  • Links
    NCBI Gene ID: 6991
    neXtProt AC: NX_Q8IZS6
    UniProt: Q8IZS6

  • Chr Location
    6q27; chr6:169725091-169751587 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit some male infertility, oligozoospermia, asthenozoospermia, and abnormal sperm morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079707 Ensembl Gene Model | MGI Sequence Detail 14337 C57BL/6J ±  kb
    transcript ENSMUST00000040746 Ensembl | MGI Sequence Detail 720 Not Applicable  
    polypeptide ENSMUSP00000036704 Ensembl | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 12
      cDNA 15

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14945, MGD-MRK-14948, MGD-MRK-14953, MGD-MRK-14955, MGD-MRK-14967, MGD-MRK-14969, MGD-MRK-4499, MGI:6456863, MGI:6458567, MGI:6459776, MGI:98648
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 2
    • Earliest
      J:8839 Rappold GA, et al., Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. EMBO J. 1987 Jul;6(7):1975-80
    • Latest
      J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory