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Tec Gene Detail
Summary
  • Symbol
    Tec
  • Name
    tec protein tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98662
    NCBI Gene: 21682
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72913059-73025826 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3693 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98662
 protein coding gene Chr5:72913059-73025997 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029617
 protein coding gene Chr5:72704245-72824345 (-)
A/J MGP_AJ_G0029585
 protein coding gene Chr5:69991865-70106265 (-)
AKR/J MGP_AKRJ_G0029533
 protein coding gene Chr5:72232171-72348326 (-)
BALB/cJ MGP_BALBcJ_G0029593
 protein coding gene Chr5:70686194-70800552 (-)
C3H/HeJ MGP_C3HHeJ_G0029318
 protein coding gene Chr5:72612900-72735099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030048
 protein coding gene Chr5:75693757-75813586 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027290
 protein coding gene Chr5:65698642-65813189 (-)
CAST/EiJ MGP_CASTEiJ_G0028727
 protein coding gene Chr5:71711668-71833315 (-)
CBA/J MGP_CBAJ_G0029286
 protein coding gene Chr5:78133696-78262726 (-)
DBA/2J MGP_DBA2J_G0029433
 protein coding gene Chr5:70038818-70159277 (-)
FVB/NJ MGP_FVBNJ_G0029393
 protein coding gene Chr5:69209338-69323287 (-)
LP/J MGP_LPJ_G0029517
 protein coding gene Chr5:73155290-73281143 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029419
 protein coding gene Chr5:81484605-81600019 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030082
 protein coding gene Chr5:71804919-71921564 (-)
PWK/PhJ MGP_PWKPhJ_G0028449
 protein coding gene Chr5:69020876-69138182 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028282
 protein coding gene Chr5:71139620-71255753 (-)
WSB/EiJ MGP_WSBEiJ_G0028807
 protein coding gene Chr5:72092646-72212226 (-)



Homology
more
  • Human Ortholog
    TEC, tec protein tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEC, tec protein tyrosine kinase
  • Synonyms
    PSCTK4
  • Links
    NCBI Gene ID: 7006
    neXtProt AC: NX_P42680
    UniProt: P42680

  • Chr Location
    4p12-p11; chr4:48135783-48269838 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    376 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a minor reduction in platetet aggregation in response to threshold concentrations of collagen-related peptide or collagen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    45
  • cDNA Data
    52
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029217 Ensembl Gene Model | MGI Sequence Detail 112768 C57BL/6J ±  kb
transcript ENSMUST00000113594 Ensembl | MGI Sequence Detail 2580 Not Applicable  
polypeptide ENSMUSP00000109224 Ensembl | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    Genomic 2
    cDNA 52
    Primer pair 1
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14989
References
more
  • Summaries
    All 433
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 11
    Phenotypes 376
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory